{"id":"W4411325981","doi":"10.1002/hon.70094_443","title":"443 | A PHASE 1 STUDY OF PRT2527, A SELECTIVE CDK9 INHIBITOR, AS MONOTHERAPY AND IN COMBINATION WITH ZANUBRUTINIB IN RELAPSED/REFRACTORY LYMPHOID MALIGNANCIES: UPDATED ANALYSIS","year":2025,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"BeiGene; Gilead Sciences; Merck KGaA; Regeneron Pharmaceuticals; Pharmacyclics; Genentech; Celgene; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; TG Therapeutics; Amgen","keywords":"Refractory (planetary science); Medicine; Oncology; Internal medicine; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000662708,0.0002256625,0.001352772,0.00109359,0.00004146966,0.000008725538,0.0001290088,0.0003679662,0.00009136739],"category_scores_gemma":[0.0004653544,0.0001653158,0.00006614636,0.003133432,0.0003112466,0.00005464325,0.00009312412,0.000395266,0.000003949151],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00542683,"about_ca_system_score_gemma":0.003824151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001112985,"about_ca_topic_score_gemma":0.001591184,"domain_scores_codex":[0.9973632,0.0005338129,0.0007565406,0.0006023514,0.0003353484,0.0004087443],"domain_scores_gemma":[0.9983194,0.0008309516,0.0002150462,0.0003095791,0.0002184438,0.0001066057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.06727837,0.07926305,0.8076046,0.0005077102,0.003037241,0.007997402,0.01132089,0.0002377463,0.01014449,0.003339905,0.0006776522,0.008590935],"study_design_scores_gemma":[0.7015423,0.0823686,0.1456533,0.0006936301,0.001673087,0.00146771,0.01635138,0.02762561,0.01799697,0.002255356,0.001543407,0.000828593],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956062,0.0004297728,0.00006517997,0.0003994443,0.00002613907,0.001671661,0.000002489548,0.00003849509,0.001760618],"genre_scores_gemma":[0.9989256,0.0000936209,0.0001995197,0.0003074963,0.000006388543,0.0002590979,0.00002068214,0.00001223916,0.0001753498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6619513,"threshold_uncertainty_score":0.9983912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02042136548820413,"score_gpt":0.366227967127734,"score_spread":0.3458066016395299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}