{"id":"W4411329812","doi":"10.1001/jama.2025.7817","title":"Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity","year":2025,"lang":"en","type":"article","venue":"JAMA","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University; Douglas Mental Health University Institute","funders":"Lawrence Berkeley National Laboratory; Department of Radiology and Biomedical Imaging, University of California, San Francisco; National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute on Deafness and Other Communication Disorders; National Institute of Mental Health; National Institute on Aging; Sahlgrenska Akademin; Korea National Institute of Health; Medical Research Council; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; HORIZON EUROPE Framework Programme; Pfizer Canada; University of California, San Francisco; National Institutes of Health; National Center for Geriatrics and Gerontology; National Institute of Neurological Disorders and Stroke; Deutsches Zentrum für Neurodegenerative Erkrankungen; Taipei Medical University; Knut och Alice Wallenbergs Stiftelse; Vetenskapsrådet; Samsung; University of Southern California; Eisai; UK Dementia Research Institute; National Research Foundation of Korea; Korea Health Industry Development Institute; Lunds Universitet; Novo Nordisk; Avid Radiopharmaceuticals; School of Medicine, Indiana University; Washington University in St. Louis; Cambridge University Hospitals; Göteborgs Universitet; National Institute for Health and Care Research; National Research Foundation; Government of Canada; University of Cambridge; Sungkyunkwan University; Genentech; European Commission; GHR Foundation; Institute for Information and Communications Technology Promotion; Prothena; Universität zu Köln; Sahlgrenska Universitetssjukhuset; University of Oxford; National Institute of Biomedical Imaging and Bioengineering; Skånes universitetssjukhus; California Department of Public Health; Faculty of Medicine, McGill University; Larry L. Hillblom Foundation; ACADIA Pharmaceuticals; Australian Catholic University; U.S. Department of Defense; Eli Lilly and Company; Demensförbundet; Alexander Family Foundation; Wallenberg Centre for Molecular and Translational Medicine; Deutsche Forschungsgemeinschaft; McGill University; Pfizer; Biogen; National Institute of Allergy and Infectious Diseases; BioClinica; University College London; Ministry of Science and ICT, South Korea; Wellcome Trust; Massachusetts General Hospital; Brigham and Women's Hospital; Alzheimer's Association; Cleveland Clinic; Bristol-Myers Squibb; Apellis Pharmaceuticals; U.S. Department of Veterans Affairs; Alzheimer's Disease Neuroimaging Initiative","keywords":"Medicine; Positron emission tomography; Positron emission; Tomography; Nuclear medicine; Medical physics; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005206749,0.0001078018,0.0002559646,0.0001352451,0.00009038678,0.0000454861,0.00004716414,0.0001099454,0.00005708982],"category_scores_gemma":[0.0004751338,0.00007224036,0.00009730882,0.0002831171,0.0001143656,0.00008822225,0.0000539243,0.0002885548,0.000004171283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003548996,"about_ca_system_score_gemma":0.0001006101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000695071,"about_ca_topic_score_gemma":0.00002521403,"domain_scores_codex":[0.9989188,0.0001467294,0.0001894386,0.0002451071,0.0002733048,0.00022664],"domain_scores_gemma":[0.9992115,0.0002811186,0.00004455794,0.0001387621,0.0001841783,0.0001398693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001967473,0.0004623619,0.9721559,0.00002367211,0.0003554088,0.00006537401,0.00001632022,4.629541e-9,0.0009501525,0.0001231514,0.00113655,0.02451434],"study_design_scores_gemma":[0.004170092,0.0007207376,0.9930137,0.0002728943,0.000228238,0.000004611808,0.00004185751,0.0000134315,0.001004301,0.0003501177,0.0001063571,0.00007363426],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742624,0.0001187533,0.0001715992,0.004646835,0.00004874077,0.0003437181,0.000008280555,0.00005241334,0.02034729],"genre_scores_gemma":[0.9946157,0.00003641954,0.0002358159,0.001315191,0.00002731645,0.00001235557,0.00003301164,0.000007340073,0.003716852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0244407,"threshold_uncertainty_score":0.2945876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357958226779412,"score_gpt":0.3487471755343801,"score_spread":0.335167593266586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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