{"id":"W4411329812","doi":"10.1001/jama.2025.7817","title":"Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity","year":2025,"lang":"en","type":"article","venue":"JAMA","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University; Douglas Mental Health University Institute","funders":"Lawrence Berkeley National Laboratory; Department of Radiology and Biomedical Imaging, University of California, San Francisco; National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute on Deafness and Other Communication Disorders; National Institute of Mental Health; National Institute on Aging; Sahlgrenska Akademin; Korea National Institute of Health; Medical Research Council; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; HORIZON EUROPE Framework Programme; Pfizer Canada; University of California, San Francisco; National Institutes of Health; National Center for Geriatrics and Gerontology; National Institute of Neurological Disorders and Stroke; Deutsches Zentrum für Neurodegenerative Erkrankungen; Taipei Medical University; Knut och Alice Wallenbergs Stiftelse; Vetenskapsrådet; Samsung; University of Southern California; Eisai; UK Dementia Research Institute; National Research Foundation of Korea; Korea Health Industry Development Institute; Lunds Universitet; Novo Nordisk; Avid Radiopharmaceuticals; School of Medicine, Indiana University; Washington University in St. Louis; Cambridge University Hospitals; Göteborgs Universitet; National Institute for Health and Care Research; National Research Foundation; Government of Canada; University of Cambridge; Sungkyunkwan University; Genentech; European Commission; GHR Foundation; Institute for Information and Communications Technology Promotion; Prothena; Universität zu Köln; Sahlgrenska Universitetssjukhuset; University of Oxford; National Institute of Biomedical Imaging and Bioengineering; Skånes universitetssjukhus; California Department of Public Health; Faculty of Medicine, McGill University; Larry L. Hillblom Foundation; ACADIA Pharmaceuticals; Australian Catholic University; U.S. Department of Defense; Eli Lilly and Company; Demensförbundet; Alexander Family Foundation; Wallenberg Centre for Molecular and Translational Medicine; Deutsche Forschungsgemeinschaft; McGill University; Pfizer; Biogen; National Institute of Allergy and Infectious Diseases; BioClinica; University College London; Ministry of Science and ICT, South Korea; Wellcome Trust; Massachusetts General Hospital; Brigham and Women's Hospital; Alzheimer's Association; Cleveland Clinic; Bristol-Myers Squibb; Apellis Pharmaceuticals; U.S. Department of Veterans Affairs; Alzheimer's Disease Neuroimaging Initiative","keywords":"Medicine; Positron emission tomography; Positron emission; Tomography; Nuclear medicine; Medical physics; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001791114,0.0003475977,0.0003793249,0.001044283,0.0004028315,0.0006360954,0.0003485876,0.0006922454,0.001004532],"category_scores_gemma":[0.007022724,0.0003242448,0.0005980968,0.001041846,0.0004256496,0.0004710985,0.0005712825,0.0004838661,0.0001305109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001977632,"about_ca_system_score_gemma":0.0001892486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00168059,"about_ca_topic_score_gemma":0.001935764,"domain_scores_codex":[0.998896,0.0003757769,0.0001301062,0.0003045759,0.0001670365,0.0001264017],"domain_scores_gemma":[0.9921061,0.001263815,0.005123021,0.0005099268,0.0005705822,0.0004266146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001280735,0.000006694848,0.9992211,0.00000401206,0.00006847487,0.00003383218,0.00001568368,0.00002595674,0.00006146383,0.000004236419,0.00002128596,0.0004090773],"study_design_scores_gemma":[0.000003806277,0.00005393978,0.9994624,0.000003200479,0.00003445988,0.0002498442,0.00003038343,0.00007723997,0.00003225167,0.00001453568,0.00003522698,0.000002639218],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998773,0.0004890115,0.0001292991,0.00002313691,0.000005024452,0.000005115753,0.0003527432,0.000003759718,0.0002188553],"genre_scores_gemma":[0.9995527,0.00006295249,0.00005052074,0.000008171015,0.000007289663,0.000004986503,0.0002728119,0.000001055568,0.00003938459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001791114,"threshold_uncertainty_score":0.00947243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357958226779412,"score_gpt":0.3487471755343801,"score_spread":0.335167593266586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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