{"id":"W4411332234","doi":"10.1002/hon.70093_134","title":"134 | EFFICACY AND SAFETY OF FIRST‐LINE IBRUTINIB PLUS VENETOCLAX IN PATIENTS WITH MANTLE CELL LYMPHOMA (MCL) WHO WERE OLDER OR HAD TP53 MUTATIONS IN THE SYMPATICO STUDY","year":2025,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Queen Elizabeth II Health Sciences Centre","funders":"Pharmacyclics","keywords":"Ibrutinib; Mantle cell lymphoma; Venetoclax; Lymphoma; Medicine; Cancer research; Oncology; Internal medicine; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004864733,0.0002072071,0.0009345671,0.0002064472,0.00008102729,0.00001048521,0.0002378723,0.0002515289,0.0001382319],"category_scores_gemma":[0.0005523568,0.0001118037,0.00004181397,0.0006880122,0.000366007,0.000035771,0.0001945849,0.0002834459,0.00001021598],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003949275,"about_ca_system_score_gemma":0.00343644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002423758,"about_ca_topic_score_gemma":0.0009616995,"domain_scores_codex":[0.9977536,0.000326136,0.000710075,0.000428226,0.0003589337,0.000423093],"domain_scores_gemma":[0.9966404,0.002624338,0.0001410702,0.0004129341,0.0001053266,0.00007588904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03065038,0.02763843,0.9037311,0.001917589,0.0003074335,0.003723722,0.01053818,0.0008322158,0.00001312242,0.002275279,0.001048307,0.01732426],"study_design_scores_gemma":[0.1690446,0.007920568,0.8129206,0.0005331496,0.0001725801,0.0001485938,0.002552328,0.004670287,0.00008567657,0.0001660238,0.001592471,0.0001930517],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929629,0.0002568341,0.00005092219,0.0008700552,0.0000399096,0.002804337,0.000007498645,0.00001965554,0.002987914],"genre_scores_gemma":[0.9989492,0.00005308412,0.0002142552,0.0003286956,0.000009713017,0.0001893423,0.00002504617,0.00001253098,0.0002181558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1383943,"threshold_uncertainty_score":0.9998744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02185390775549227,"score_gpt":0.3318345856293453,"score_spread":0.309980677873853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}