{"id":"W4411333157","doi":"10.21203/rs.3.rs-6148216/v1","title":"Biodialyzed Palladium catalysis enables bioorthogonal drug release to control epithelial progenitor cell differentiation","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; Agencia Estatal de Investigación; Biotechnology and Biological Sciences Research Council; UK Research and Innovation; Engineering and Physical Sciences Research Council; Medical Research Council; Junta de Andalucía; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina; University of Edinburgh; Consejería de Transformación Económica, Industria, Conocimiento y Universidades; Ministerio de Ciencia, Innovación y Universidades; Horizon 2020 Framework Programme; European Synchrotron Radiation Facility; Wellcome Trust","keywords":"Bioorthogonal chemistry; Palladium; Progenitor cell; Chemistry; Catalysis; Progenitor; Combinatorial chemistry; Drug; Cell biology; Stem cell; Biochemistry; Pharmacology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006815612,0.0004909992,0.0006050684,0.0003508123,0.0005407577,0.000340371,0.001139498,0.0006008183,0.001556622],"category_scores_gemma":[0.0006604962,0.0004983717,0.0004982627,0.0006345552,0.0001529249,0.00004660178,0.001149223,0.001680884,0.0002720983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000498722,"about_ca_system_score_gemma":0.0009784545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008611179,"about_ca_topic_score_gemma":0.0001750446,"domain_scores_codex":[0.9957572,0.0001905876,0.000671907,0.001352473,0.001045487,0.0009824117],"domain_scores_gemma":[0.995836,0.0007125758,0.0002096921,0.001689288,0.0009309853,0.0006214275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005488724,0.001408345,0.004229056,0.007148191,0.0004084938,0.00002733662,0.0007315295,0.0004446673,0.9702457,0.0001399091,0.01082736,0.003840588],"study_design_scores_gemma":[0.001155628,0.00001383183,0.0003384756,0.0005716641,0.0001775141,9.475391e-7,0.0003439852,0.0007582011,0.9697202,0.0005715501,0.02579935,0.0005486083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98,0.0004653903,0.000313048,0.002899901,0.0001325009,0.001251806,0.01005201,0.0002404785,0.004644846],"genre_scores_gemma":[0.974132,0.0001721126,0.0001815037,0.0000360417,0.001279263,0.002896406,0.005176214,0.00004567075,0.01608077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01497199,"threshold_uncertainty_score":0.9997468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02576211651423799,"score_gpt":0.3305118784702796,"score_spread":0.3047497619560416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}