{"id":"W4411334570","doi":"10.1016/j.npep.2025.102534","title":"Neuroprotective effect of Ac-SDKP peptide in SH-SY5Y cells and rat model of Parkinson's disease against 6-OHDA-induced oxidative stress and ER stress","year":2025,"lang":"en","type":"article","venue":"Neuropeptides","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Tehran University of Medical Sciences and Health Services","keywords":"Neuroprotection; Oxidative stress; Dopaminergic; Pharmacology; SH-SY5Y; Unfolded protein response; Neurodegeneration; Neuroscience; Neuroinflammation; Cytoprotection; Endoplasmic reticulum; Medicine; Chemistry; Biology; Internal medicine; Cell biology; Dopamine; Inflammation; Cell culture; Disease; Neuroblastoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001550069,0.0003597106,0.0005608569,0.000318481,0.0002533846,0.0002177673,0.0001937478,0.0004033879,0.001228426],"category_scores_gemma":[0.0001088175,0.0001318736,0.0002508845,0.0002570177,0.0003073765,0.0004115682,0.0001456633,0.0009315117,0.0001868073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001667302,"about_ca_system_score_gemma":0.0003800993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001153573,"about_ca_topic_score_gemma":0.001370513,"domain_scores_codex":[0.9999194,0.000008597179,0.000009652822,0.00001329354,0.0000156229,0.00003337888],"domain_scores_gemma":[0.9999274,0.00000831398,0.0000133235,0.000007263488,0.00001134374,0.00003238894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003467008,0.0006590066,0.0003855487,0.000305438,0.00003529564,0.0003392606,0.0000757067,0.0001537134,0.9890378,0.0002698477,0.0002127449,0.005058572],"study_design_scores_gemma":[0.0005004533,0.009185317,0.01215273,0.00004114579,0.000161491,0.0006215798,0.000190317,0.00114878,0.9725581,0.0002115806,0.003207226,0.00002128472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995146,0.002972077,0.0003931493,0.0001227459,0.00007760025,0.00002406148,0.0002500971,0.00003170749,0.0009826191],"genre_scores_gemma":[0.9941156,0.002794178,0.0008439511,0.00005139393,0.00003456723,0.00004206789,0.0003900366,0.000004818213,0.00172336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001228426,"threshold_uncertainty_score":0.004109502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006347650502430639,"score_gpt":0.2316265359731169,"score_spread":0.2252788854706863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}