{"id":"W4411340484","doi":"10.1210/endrev/bnaf018","title":"The Impact of Estrogen Deficiency on Liver Metabolism: Implications for Hormone Replacement Therapy","year":2025,"lang":"en","type":"article","venue":"Endocrine Reviews","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Oxford Biomedical Research Centre; Tasmanian Department of Health; Medical Research Council Canada; British Heart Foundation; National Institute for Health and Care Research","keywords":"Estrogen; Hormone replacement therapy (female-to-male); Medicine; Menopause; Endocrinology; Insulin resistance; Internal medicine; Liver disease; Steatosis; Adipose tissue; Chronic liver disease; Hormone; Nonalcoholic fatty liver disease; Disease; Fatty liver; Diabetes mellitus; Testosterone (patch); Cirrhosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001715375,0.00014463,0.0003774032,0.00005018724,0.000114642,0.00001132452,0.0001034888,0.00001143533,0.00002943743],"category_scores_gemma":[0.0001173563,0.0000689961,0.0005148042,0.0001874339,0.00003167757,0.00002150163,0.00002229173,0.00004242895,0.00001650087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007928035,"about_ca_system_score_gemma":0.0001078019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007645661,"about_ca_topic_score_gemma":0.00000125611,"domain_scores_codex":[0.9991339,0.00005053699,0.0003524205,0.0001980565,0.00007685039,0.0001882632],"domain_scores_gemma":[0.9989327,0.0001846961,0.0001289821,0.0005967966,0.00009165654,0.00006513797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00154683,0.00391994,0.02766715,0.0002321138,0.001274276,0.000003392719,0.0001061493,0.000007681055,0.001471229,0.05907406,0.1547132,0.749984],"study_design_scores_gemma":[0.003089331,0.001046147,0.3850475,0.0001217277,0.0005075337,0.000005335858,0.00001248498,0.00001383416,0.001973804,0.0004390411,0.6076606,0.00008263034],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1284601,0.8563128,0.000130934,0.00414128,0.00009065607,0.005923947,0.0001113186,0.00002852536,0.004800449],"genre_scores_gemma":[0.5067083,0.4890149,0.0004443222,0.0003534461,0.00008051904,0.002547875,0.00006193653,0.00001424696,0.0007744461],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.7499014,"threshold_uncertainty_score":0.2813579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05166970564542705,"score_gpt":0.3964450597500619,"score_spread":0.3447753541046348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}