{"id":"W4411340484","doi":"10.1210/endrev/bnaf018","title":"The Impact of Estrogen Deficiency on Liver Metabolism: Implications for Hormone Replacement Therapy","year":2025,"lang":"en","type":"article","venue":"Endocrine Reviews","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Oxford Biomedical Research Centre; Tasmanian Department of Health; Medical Research Council Canada; British Heart Foundation; National Institute for Health and Care Research","keywords":"Estrogen; Hormone replacement therapy (female-to-male); Medicine; Menopause; Endocrinology; Insulin resistance; Internal medicine; Liver disease; Steatosis; Adipose tissue; Chronic liver disease; Hormone; Nonalcoholic fatty liver disease; Disease; Fatty liver; Diabetes mellitus; Testosterone (patch); Cirrhosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001004749,0.000304912,0.0009612729,0.0006611008,0.0001665592,0.0007571125,0.0004370152,0.0008140773,0.003158129],"category_scores_gemma":[0.001653306,0.0001304578,0.0005642744,0.0005829259,0.0003857796,0.0005416222,0.0003646799,0.001266665,0.000790755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005545497,"about_ca_system_score_gemma":0.000903932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001208714,"about_ca_topic_score_gemma":0.002457448,"domain_scores_codex":[0.9997213,0.0001044381,0.00004775982,0.00002900273,0.00007219025,0.00002514187],"domain_scores_gemma":[0.9992732,0.0004821489,0.00007848015,0.0000151261,0.0001155513,0.00003543996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004102988,0.00009812955,0.001118729,0.01175062,0.0002273353,0.0005974999,0.0001319387,0.0004741541,0.001967279,0.006346663,0.04182306,0.9350542],"study_design_scores_gemma":[0.0001288336,0.0004517287,0.004853025,0.009728331,0.0003595988,0.002543921,0.0002364624,0.0001870561,0.0006403943,0.006630958,0.9742064,0.00003322938],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002884314,0.9967753,0.00006039074,0.002012844,0.0002320783,0.000002080864,0.00002077801,0.000003365092,0.0006045957],"genre_scores_gemma":[0.002921625,0.9948629,0.0001908029,0.0008274034,0.0006824497,0.000008443898,0.00002956195,0.00000181125,0.0004750014],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003158129,"threshold_uncertainty_score":0.01056498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05166970564542705,"score_gpt":0.3964450597500619,"score_spread":0.3447753541046348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}