{"id":"W4411340744","doi":"10.1016/j.ymgme.2025.109179","title":"The mitochondrial disease biomarker GDF15 is dynamic, quantifiable in saliva, and correlates with disease severity","year":2025,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Institute on Aging; National Institute of Mental Health; Nathaniel Wharton Fund","keywords":"Biomarker; Disease; Saliva; GDF15; Medicine; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008688503,0.0006312606,0.0006049956,0.001163984,0.0002521588,0.001134296,0.0003501132,0.0009969135,0.001072427],"category_scores_gemma":[0.002221205,0.0002236009,0.0004550358,0.000630573,0.0004109061,0.0004709207,0.0006037637,0.0005774747,0.0003560744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004166269,"about_ca_system_score_gemma":0.000245537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001847913,"about_ca_topic_score_gemma":0.002144004,"domain_scores_codex":[0.9993293,0.000140149,0.00006714543,0.0001990966,0.0001883754,0.00007589268],"domain_scores_gemma":[0.9992067,0.0001280374,0.0003839299,0.00005409132,0.0001266617,0.0001006301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0013244,0.000141411,0.8229276,0.0002189638,0.0006630282,0.0004441213,0.0003585535,0.0002772728,0.129645,0.0002687715,0.001396645,0.04233417],"study_design_scores_gemma":[0.00002747827,0.0006812289,0.9540488,0.0001015256,0.0002105897,0.003188779,0.0003620816,0.0008140212,0.03611154,0.0006185859,0.003796158,0.00003932727],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866905,0.007383908,0.002240218,0.0003111379,0.0001020982,0.00003739351,0.001763308,0.0001341544,0.0013373],"genre_scores_gemma":[0.9953843,0.0009053356,0.001672411,0.0001684449,0.0000343124,0.00002624788,0.0009717156,0.0000125544,0.0008248251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001847913,"threshold_uncertainty_score":0.004594982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003884738471932226,"score_gpt":0.2357367012445213,"score_spread":0.2318519627725891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}