{"id":"W4411340744","doi":"10.1016/j.ymgme.2025.109179","title":"The mitochondrial disease biomarker GDF15 is dynamic, quantifiable in saliva, and correlates with disease severity","year":2025,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Institute on Aging; National Institute of Mental Health; Nathaniel Wharton Fund","keywords":"Biomarker; Disease; Saliva; GDF15; Medicine; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001181147,0.0002076215,0.0002445083,0.0001136981,0.0001579753,0.00007716569,0.00007563216,0.00009928458,0.000006731856],"category_scores_gemma":[0.00005410932,0.0001305682,0.00006652531,0.0002741101,0.0002691417,0.00002210527,0.00009147896,0.0001629842,0.000001835779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001248751,"about_ca_system_score_gemma":0.0001607605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004506854,"about_ca_topic_score_gemma":0.00001907491,"domain_scores_codex":[0.9988433,0.00006964547,0.0002185799,0.0003845358,0.0001949417,0.0002890276],"domain_scores_gemma":[0.9991703,0.00003824752,0.00004522753,0.0003636132,0.00006243119,0.0003201881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0238987,0.002031627,0.4530723,0.001809398,0.005065269,0.004276213,0.001419685,0.0002169343,0.2999781,0.01107217,0.01085456,0.186305],"study_design_scores_gemma":[0.004166975,0.00003698331,0.9163629,0.0002363135,0.001205219,0.00001497732,0.0000859007,0.01328025,0.001092014,0.002606812,0.06060987,0.0003018277],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.895317,0.09996989,0.0004002835,0.003158983,0.0003707194,0.0005257799,0.00002712184,0.00001711614,0.0002131814],"genre_scores_gemma":[0.9881411,0.008828402,0.0005740183,0.0008269238,0.00001598192,0.00002806888,0.00002726576,0.00002361798,0.001534683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4632905,"threshold_uncertainty_score":0.5324416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003884738471932226,"score_gpt":0.2357367012445213,"score_spread":0.2318519627725891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}