{"id":"W4411344746","doi":"10.1038/s42003-025-08355-7","title":"Lewy-MSA hybrid fold drives distinct neuronal α-synuclein pathology","year":2025,"lang":"en","type":"article","venue":"Communications Biology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; University Health Network; University of Toronto; Princess Margaret Cancer Centre; Toronto Western Hospital; Occupational Cancer Research Centre","funders":"National Institute on Aging; National Health and Medical Research Council; Medical Research Council; U.S. Department of Health and Human Services; National Institutes of Health; Edmond J. Safra Philanthropic Foundation","keywords":"Pathology; Fold (higher-order function); Lewy body; Neuroscience; Medicine; Parkinson's disease; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008262249,0.000175982,0.0001098255,0.0001493301,0.0001553943,0.0002515055,0.00009331395,0.0002377998,0.0007596402],"category_scores_gemma":[0.00009633152,0.00009604606,0.0001238296,0.0000683866,0.0001770417,0.000131717,0.0002074307,0.0002793851,0.0001813838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002193812,"about_ca_system_score_gemma":0.0000850962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002792171,"about_ca_topic_score_gemma":0.0007197333,"domain_scores_codex":[0.9999145,0.00001175228,0.00001096213,0.00002328713,0.00002411412,0.00001538554],"domain_scores_gemma":[0.9999008,0.00001576822,0.0000276834,0.00001263614,0.00001150484,0.00003160009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005829224,0.00001975341,0.0008060521,0.00001015934,0.000004886809,0.0001670428,0.00002096047,0.00002582015,0.9981559,0.0001799952,0.0000180825,0.0005330741],"study_design_scores_gemma":[0.00001552171,0.0006402067,0.05966672,0.00001173892,0.0000242937,0.004176518,0.0001453729,0.002629643,0.9295285,0.0004428946,0.002709352,0.00000931816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982426,0.0002102857,0.0007778362,0.00001845955,0.000004743175,0.000007077595,0.00005845352,0.0000247889,0.0006556634],"genre_scores_gemma":[0.9985325,0.00006266146,0.0005687684,0.00001550717,0.000001551709,0.000005493211,0.0001528726,0.000003473428,0.0006572044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007596402,"threshold_uncertainty_score":0.002541244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03095508194460345,"score_gpt":0.3259781112725368,"score_spread":0.2950230293279333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}