{"id":"W4411347414","doi":"10.2337/db25-0393","title":"Therapeutic Targeting of the GIP Receptor—Revisiting the Controversies","year":2025,"lang":"en","type":"review","venue":"Diabetes","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research","keywords":"Agonism; Exenatide; Antagonism; Receptor; Glucagon-like peptide 1 receptor; Glucagon-like peptide-1; Body weight; Biology; Medicine; Internal medicine; Endocrinology; Diabetes mellitus; Type 2 diabetes; Political science; Agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002617689,0.000917407,0.00189532,0.002183057,0.0002897249,0.001842897,0.001519168,0.00197996,0.003397618],"category_scores_gemma":[0.002904619,0.0002859977,0.0008974095,0.001861475,0.001175644,0.003493038,0.0009860229,0.003990629,0.001279074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008414095,"about_ca_system_score_gemma":0.002172909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008058302,"about_ca_topic_score_gemma":0.001819524,"domain_scores_codex":[0.9995199,0.0001452255,0.00009058251,0.00007585635,0.0001296934,0.0000387443],"domain_scores_gemma":[0.9983227,0.001197726,0.0001511102,0.0000425931,0.00023471,0.00005117454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002161477,0.000107771,0.0001460732,0.05205911,0.0002695742,0.0003113711,0.0001559624,0.0003807331,0.001334512,0.01997989,0.02917444,0.8958645],"study_design_scores_gemma":[0.00006574981,0.0001714816,0.0006131491,0.0360036,0.00045823,0.001065141,0.0002836554,0.0001767941,0.0003970338,0.0136883,0.9470475,0.00002925766],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005260426,0.998229,0.00006778474,0.001047344,0.0002928249,0.00000194916,0.000005756678,0.00000260023,0.0003003093],"genre_scores_gemma":[0.0005579618,0.9980708,0.0001192312,0.0007044119,0.0003992195,0.000004364206,0.000009853252,0.000001299638,0.0001328888],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003397618,"threshold_uncertainty_score":0.01384383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02007990396009569,"score_gpt":0.2880096920109276,"score_spread":0.267929788050832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}