{"id":"W4411348048","doi":"10.1002/ana.27288","title":"Blood α‐Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies","year":2025,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute on Aging; National Institutes of Health; Demensförbundet; Parkinsonfonden; Weston Brain Institute; University of Pennsylvania; National Institute of Neurological Disorders and Stroke; Alzheimer's Association; American Heart Association; Children's Hospital of Philadelphia","keywords":"Dementia with Lewy bodies; Alpha-synuclein; Cerebrospinal fluid; Western blot; Antibody; Lewy body; Pathology; Monoclonal antibody; Cognitive decline; Parkinson's disease; Biomarker; Dementia; Immunohistochemistry; Biology; Disease; Chemistry; Immunology; Medicine; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002367905,0.0004233471,0.0002113654,0.0008386733,0.0001842502,0.0004232214,0.000122945,0.0004632461,0.0009963115],"category_scores_gemma":[0.0006217225,0.0001586808,0.0001306369,0.0002711929,0.0002179025,0.0002835174,0.0001858448,0.0002459475,0.0002881921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001305482,"about_ca_system_score_gemma":0.0001013617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004217025,"about_ca_topic_score_gemma":0.0005449465,"domain_scores_codex":[0.9998864,0.00001869084,0.00002216476,0.0000373556,0.0000213439,0.00001404016],"domain_scores_gemma":[0.9997136,0.00006708878,0.00009386639,0.0000157148,0.00005355067,0.00005620284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002395295,0.0001543066,0.2652561,0.000203277,0.0001286724,0.001107374,0.0003757241,0.0001071597,0.7165564,0.0001536611,0.0003588383,0.01320322],"study_design_scores_gemma":[0.00007078137,0.001114961,0.9092453,0.00006050608,0.0001116941,0.006538441,0.000292721,0.00130905,0.07913324,0.0003300253,0.001778543,0.00001469026],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971632,0.001136109,0.0007581138,0.00002801708,0.00001746072,0.00001266313,0.0001276129,0.0000242997,0.0007325407],"genre_scores_gemma":[0.99731,0.0004896873,0.001427079,0.00005049881,0.00002809109,0.00001014873,0.0003752291,0.000008157792,0.0003010024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009963115,"threshold_uncertainty_score":0.003333032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02637504220910989,"score_gpt":0.2970188314843786,"score_spread":0.2706437892752687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}