{"id":"W4411350887","doi":"10.3390/electronics14122442","title":"Multimodal Gene Expression and Methylation Profiling Reveals Misclassified Tumors Beyond Histological Diagnosis","year":2025,"lang":"en","type":"article","venue":"Electronics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thompson Rivers University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Methylation; Profiling (computer programming); Gene expression profiling; DNA methylation; Pathology; Computational biology; Gene expression; Biology; Gene; Cancer research; Medicine; Genetics; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001563507,0.0001382985,0.0001548542,0.00004420649,0.0001420471,0.00003571142,0.0001034045,0.0001672494,0.00000765793],"category_scores_gemma":[0.0002545473,0.0001333356,0.00005242397,0.00007606897,0.00005016771,0.000002913045,0.0001090221,0.0001254351,0.000001090507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006999903,"about_ca_system_score_gemma":0.0001476081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000647095,"about_ca_topic_score_gemma":0.0000283798,"domain_scores_codex":[0.9990534,0.00004643732,0.0001978912,0.0003671411,0.00007158231,0.0002635111],"domain_scores_gemma":[0.9995437,0.00005984461,0.00007125659,0.0002163572,0.0000527004,0.00005615416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007811104,0.00004791347,0.01100585,0.00001838648,0.00002412857,0.000001826053,0.00001736147,0.00008201382,0.9803746,0.001419142,0.001778964,0.0051517],"study_design_scores_gemma":[0.0005379043,0.0001870372,0.003266765,0.0000168251,0.00002942598,0.000003689217,0.00001442837,0.000266895,0.9631677,0.00192144,0.03041958,0.000168349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9640651,0.0307035,0.003874349,0.0002827462,0.0001181813,0.0002448602,0.00002203616,0.00001516989,0.000673994],"genre_scores_gemma":[0.989474,0.004061121,0.005333635,0.0003986056,0.0001068088,0.00009175533,0.0001668399,0.00001383154,0.000353412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02864061,"threshold_uncertainty_score":0.5437269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009259528460221269,"score_gpt":0.2560176246230861,"score_spread":0.2467580961628649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}