{"id":"W4411350887","doi":"10.3390/electronics14122442","title":"Multimodal Gene Expression and Methylation Profiling Reveals Misclassified Tumors Beyond Histological Diagnosis","year":2025,"lang":"en","type":"article","venue":"Electronics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thompson Rivers University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Methylation; Profiling (computer programming); Gene expression profiling; DNA methylation; Pathology; Computational biology; Gene expression; Biology; Gene; Cancer research; Medicine; Genetics; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001319841,0.000632547,0.000679551,0.0009662115,0.000243088,0.0009272852,0.000368571,0.0005888921,0.000769223],"category_scores_gemma":[0.002276741,0.0002052978,0.0003386264,0.0007083006,0.0004674711,0.0004198051,0.0005454292,0.0004724219,0.0002750343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004326548,"about_ca_system_score_gemma":0.0003017909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001224762,"about_ca_topic_score_gemma":0.002588408,"domain_scores_codex":[0.9991066,0.0001952277,0.00006000572,0.0002895944,0.0002555774,0.00009299232],"domain_scores_gemma":[0.9992509,0.0002787857,0.0001945069,0.0001308235,0.0001103486,0.00003458255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009146787,0.0001620961,0.2437267,0.0002644919,0.0002909808,0.0003805198,0.0003783869,0.01860812,0.5675174,0.001340264,0.000929365,0.1654871],"study_design_scores_gemma":[0.00002838648,0.0005053129,0.2023249,0.00006207105,0.0003228378,0.001025889,0.0003527289,0.2913902,0.4944887,0.00613193,0.003283914,0.00008300877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8768582,0.001150327,0.1186315,0.0003034354,0.00004130166,0.00005394042,0.0007178954,0.0009190896,0.001324422],"genre_scores_gemma":[0.9679145,0.0001711173,0.03070651,0.00009114332,0.00001113489,0.00003232909,0.0004214084,0.00004866937,0.0006031117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001319841,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009259528460221269,"score_gpt":0.2560176246230861,"score_spread":0.2467580961628649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}