{"id":"W4411370089","doi":"10.1016/j.jtha.2025.06.002","title":"2025 focused update of the 2020 ISTH guidelines for management of thrombotic thrombocytopenic purpura","year":2025,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute; McMaster University Medical Centre","funders":"National Heart, Lung, and Blood Institute","keywords":"Thrombotic thrombocytopenic purpura; Medicine; Intensive care medicine; Thrombocytopenic purpura; Purpura (gastropod); Internal medicine; Platelet; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005980445,0.0001909804,0.0008269831,0.0001243113,0.0001622538,0.00001865895,0.00057588,0.00008909751,0.0002938404],"category_scores_gemma":[0.0001100398,0.0001244673,0.0004260481,0.0002754479,0.0002266537,0.0001004489,0.0002979843,0.0001142253,0.000003107688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000429205,"about_ca_system_score_gemma":0.0001045667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002589251,"about_ca_topic_score_gemma":0.00001504225,"domain_scores_codex":[0.9980633,0.0001458888,0.001278028,0.0001862731,0.0001096388,0.0002168427],"domain_scores_gemma":[0.9977617,0.0001825423,0.001000461,0.0004036097,0.0006293748,0.00002227767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0009339135,0.0009952803,0.02833616,0.002902478,0.01376707,0.000003432394,0.0004121683,0.0001108229,0.0594299,0.02050125,0.8408579,0.03174961],"study_design_scores_gemma":[0.01985947,0.001364909,0.4487025,0.008136787,0.0102007,0.00006151897,0.005855802,0.00005334464,0.3559245,0.01317327,0.1358561,0.0008111365],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9572046,0.02077206,0.001332777,0.01629379,0.002009684,0.001325521,0.0003347428,0.00001283013,0.0007139451],"genre_scores_gemma":[0.994146,0.003123199,0.00200079,0.0003525931,0.00002915286,0.00001478011,0.000009532013,0.00001317837,0.0003107961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7050018,"threshold_uncertainty_score":0.507563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1000064734516885,"score_gpt":0.3786444513748364,"score_spread":0.2786379779231479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}