{"id":"W4411371346","doi":"10.7554/elife.105311.2.sa4","title":"eLife Assessment: Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control in HeLa cells","year":2025,"lang":"en","type":"peer-review","venue":"","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Translation (biology); HeLa; Control (management); Biology; Cell biology; Computer science; Computational biology; Genetics; Artificial intelligence; Cell; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004231417,0.0002857416,0.0004449186,0.0003608043,0.00003786742,0.00004303594,0.0001118755,0.0004685052,0.0001610872],"category_scores_gemma":[0.0000444792,0.0003065999,0.0001081936,0.0002556302,0.0000541903,0.000013517,0.00001659206,0.0002356563,0.000002550878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003948267,"about_ca_system_score_gemma":0.0005205034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001447458,"about_ca_topic_score_gemma":0.004815659,"domain_scores_codex":[0.9979854,0.0002462019,0.0007516107,0.0005178771,0.0002695725,0.0002292899],"domain_scores_gemma":[0.9994299,0.00006076231,0.0001504912,0.0001834524,0.0000910126,0.0000843435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00311614,0.004682668,0.193107,0.01211156,0.0005853505,0.0001360427,0.0008086077,0.005652706,0.5392871,0.001139373,0.1836563,0.05571714],"study_design_scores_gemma":[0.02846588,0.0003422145,0.4035968,0.003658984,0.0003044657,0.00000405927,0.0001074116,0.02418123,0.002115221,0.0004927464,0.5348289,0.001902086],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4835209,0.2873402,0.008948084,0.109535,0.001713755,0.01562196,0.007187952,0.0001619142,0.08597025],"genre_scores_gemma":[0.9718286,0.003790624,0.0003115785,0.003084244,0.0001250379,0.0002177846,0.01698333,0.00002848223,0.003630323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5371719,"threshold_uncertainty_score":0.9999386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0195324626459381,"score_gpt":0.3094549990087787,"score_spread":0.2899225363628406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}