{"id":"W4411372387","doi":"10.1103/szpk-sx1c","title":"Evolutionary Benefits of Fitness-Dependent Mutation Rates","year":2025,"lang":"en","type":"article","venue":"Physical Review Letters","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Science Foundation","keywords":"Mutation; Mutation rate; Biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009771925,0.0007082262,0.0005282903,0.0005047255,0.0005127196,0.001213105,0.0008242017,0.001546135,0.002005867],"category_scores_gemma":[0.008661213,0.0003482598,0.0005228258,0.0002977128,0.0008203733,0.001486382,0.001049931,0.001194592,0.0002821723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005792707,"about_ca_system_score_gemma":0.0003962067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008378553,"about_ca_topic_score_gemma":0.0006506159,"domain_scores_codex":[0.9995165,0.000192739,0.00002326492,0.00008119936,0.000105231,0.00008118117],"domain_scores_gemma":[0.9976491,0.001346927,0.0003321582,0.0003354207,0.0001626783,0.0001736168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002997961,0.0002000509,0.01150581,0.0002503738,0.0002260184,0.001007682,0.0002111751,0.624593,0.07180692,0.2608586,0.001366699,0.02767394],"study_design_scores_gemma":[0.0001048184,0.0003279162,0.01551218,0.00005435518,0.0001373324,0.0008975471,0.0001367939,0.8576508,0.005823596,0.1167651,0.002489675,0.00009995865],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8798962,0.001065264,0.09658698,0.002040996,0.0001145428,0.00003400625,0.0001359978,0.000254215,0.01987191],"genre_scores_gemma":[0.99362,0.0003232051,0.004736043,0.0001184347,0.00002808509,0.00001852148,0.00002483502,0.00003664761,0.001094197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002005867,"threshold_uncertainty_score":0.006710351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007865862748103464,"score_gpt":0.2926628005361397,"score_spread":0.2847969377880363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}