{"id":"W4411374384","doi":"10.1186/s13024-025-00863-8","title":"sPLA2-IIA modifies progranulin deficiency phenotypes in mouse models","year":2025,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Aging","keywords":"Phenotype; Frontotemporal lobar degeneration; Haploinsufficiency; Biology; Neurodegeneration; Western blot; Genetics; Medicine; Pathology; Gene; Frontotemporal dementia; Dementia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000171406,0.0001581704,0.0002083788,0.0002736507,0.0000773098,0.00006438483,0.0001202283,0.0001016139,0.00001864172],"category_scores_gemma":[0.00008347374,0.0001432966,0.00006840128,0.0005156522,0.00005604393,0.0001378484,0.00007004886,0.0002380665,0.00002115108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009297433,"about_ca_system_score_gemma":0.0001250771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001501516,"about_ca_topic_score_gemma":0.00005292087,"domain_scores_codex":[0.9984729,0.0001232514,0.0002975082,0.000414078,0.0003748079,0.0003174102],"domain_scores_gemma":[0.9994015,0.00001416609,0.00003236769,0.0003620654,0.0001200185,0.00006989932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001275016,0.0002150475,0.0009122345,0.00006806415,0.000009205467,0.00005473431,0.00009696902,0.0340087,0.9523936,0.008012344,0.0001429427,0.00395868],"study_design_scores_gemma":[0.002121445,0.0002797546,0.013745,0.00009493287,0.00004264841,0.000009360291,0.00001652872,0.3110483,0.6692633,0.002916321,0.0001923214,0.0002701147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97046,0.0004630716,0.02368448,0.001984508,0.00007151014,0.0007026954,0.000003055786,0.00007946209,0.002551225],"genre_scores_gemma":[0.9961256,0.00007596294,0.001496211,0.0008222692,0.00002758868,0.00009516996,0.00004568085,0.00002346302,0.001288065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2831303,"threshold_uncertainty_score":0.5843466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02246766078585287,"score_gpt":0.2876984293588036,"score_spread":0.2652307685729507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}