{"id":"W4411374384","doi":"10.1186/s13024-025-00863-8","title":"sPLA2-IIA modifies progranulin deficiency phenotypes in mouse models","year":2025,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Aging","keywords":"Phenotype; Frontotemporal lobar degeneration; Haploinsufficiency; Biology; Neurodegeneration; Western blot; Genetics; Medicine; Pathology; Gene; Frontotemporal dementia; Dementia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004808238,0.001070528,0.0004702971,0.001383399,0.0003588606,0.0006176393,0.0004554655,0.0009755163,0.003260172],"category_scores_gemma":[0.0002244416,0.0003765869,0.0006830248,0.0003925726,0.0006107629,0.0003728688,0.0004525608,0.00176411,0.001264779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006724611,"about_ca_system_score_gemma":0.0003811907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000832087,"about_ca_topic_score_gemma":0.001374017,"domain_scores_codex":[0.9995846,0.00005629739,0.00005486807,0.0001289349,0.0001168036,0.00005856342],"domain_scores_gemma":[0.9995308,0.00003830166,0.0001923648,0.00003825259,0.00004130987,0.0001589808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000299939,0.00006778741,0.0006363094,0.00009655626,0.00002738875,0.0002906524,0.00002497899,0.0001153953,0.9967795,0.0001502121,0.0001669097,0.001344433],"study_design_scores_gemma":[0.0001467848,0.0008383556,0.01592964,0.00008979188,0.0002037227,0.002941627,0.0001155414,0.002549837,0.9658102,0.0003248422,0.01101851,0.00003132704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761941,0.003288275,0.0102189,0.000541697,0.0001523763,0.0001438797,0.005223543,0.0008896976,0.003347561],"genre_scores_gemma":[0.9692318,0.003046323,0.009877224,0.0004613502,0.00003752254,0.0003930342,0.006393773,0.0004364552,0.01012243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003260172,"threshold_uncertainty_score":0.01090634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02246766078585287,"score_gpt":0.2876984293588036,"score_spread":0.2652307685729507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}