{"id":"W4411376073","doi":"10.1021/acsorginorgau.5c00038","title":"Noyori–Ikariya Asymmetric Transfer Hydrogenation of Prochiral α-CF<sub>3</sub> and α-SF<sub>5</sub> Ketones","year":2025,"lang":"en","type":"article","venue":"ACS Organic & Inorganic Au","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Université Laval","keywords":"Enantioselective synthesis; Chemistry; Transfer hydrogenation; Electronegativity; Steric effects; Trifluoromethyl; Enantiomer; Lipophilicity; Ketone; Noyori asymmetric hydrogenation; Stereoisomerism; Asymmetric hydrogenation; Organic chemistry; Combinatorial chemistry; Catalysis; Stereochemistry; Alkyl","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001666874,0.0003793345,0.0001925755,0.0001471816,0.0001440784,0.0001541852,0.000313048,0.0002426364,0.001671247],"category_scores_gemma":[0.0001289068,0.0001269901,0.0001861546,0.0001516923,0.000219044,0.0003829806,0.0002907665,0.0005770697,0.0004536345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001510929,"about_ca_system_score_gemma":0.0001652182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007872855,"about_ca_topic_score_gemma":0.001529688,"domain_scores_codex":[0.9998811,0.00001474962,0.000006744914,0.00002367711,0.00002538377,0.00004816892],"domain_scores_gemma":[0.9999512,0.00000903511,0.00001239252,0.000007987567,0.000008364132,0.00001097565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001671207,0.00002541153,0.0001986259,0.0001016349,0.00001311107,0.0002808987,0.000108815,0.0002596885,0.9864538,0.001089305,0.0006525537,0.01064899],"study_design_scores_gemma":[0.00001270021,0.0001033391,0.000702102,0.0000040479,0.000007820217,0.0001528388,0.00003638635,0.0007541778,0.9950004,0.0001023209,0.003114915,0.000008966222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9538902,0.002060455,0.02194704,0.0004154074,0.0001742131,0.00006437572,0.0004688826,0.0002590955,0.02072024],"genre_scores_gemma":[0.9902844,0.001090793,0.004425087,0.00007421357,0.00001981796,0.00002170831,0.0001700106,0.0000285324,0.003885459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001671247,"threshold_uncertainty_score":0.005590916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02852893384328524,"score_gpt":0.3177068921685048,"score_spread":0.2891779583252195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}