{"id":"W4411377719","doi":"10.1002/gepi.70013","title":"A Robust Association Test Leveraging Unknown Genetic Interactions: Application to Cystic Fibrosis Lung Disease","year":2025,"lang":"en","type":"article","venue":"Genetic Epidemiology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; Public Health Ontario; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Institute of Circulatory and Respiratory Health; University of Toronto; Government of Ontario; Canada Research Chairs; Government of Canada; Canadian Institutes of Health Research; Genome Canada","keywords":"Genome-wide association study; Quantitative trait locus; Biology; Genetic association; Genetics; Normality; Trait; Cystic fibrosis; Genetic architecture; Computational biology; Genotype; Evolutionary biology; Gene; Statistics; Single-nucleotide polymorphism; Computer science; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01976964,0.0007818263,0.001453963,0.001511008,0.0006376912,0.001121439,0.002062049,0.001241242,0.002644334],"category_scores_gemma":[0.07198127,0.000406413,0.001549331,0.002246988,0.00168364,0.001135968,0.001852527,0.001712282,0.0004804115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007969421,"about_ca_system_score_gemma":0.002594285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01363739,"about_ca_topic_score_gemma":0.009111859,"domain_scores_codex":[0.9914925,0.005722139,0.0003095875,0.00119571,0.001050257,0.0002299329],"domain_scores_gemma":[0.9481202,0.04522811,0.001969892,0.002416128,0.001710928,0.0005547227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00230433,0.0002870557,0.1046952,0.0007008826,0.002345086,0.002506484,0.0003681892,0.3248003,0.01147404,0.06212032,0.007900416,0.4804977],"study_design_scores_gemma":[0.000482924,0.0004175035,0.0189973,0.00005112599,0.0003135355,0.0006292417,0.00008109254,0.9233044,0.001531948,0.04959569,0.004489067,0.0001061082],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.06519877,0.001170404,0.9289302,0.001153378,0.000135377,0.0001464998,0.0007409385,0.001177922,0.001346555],"genre_scores_gemma":[0.6979924,0.0006266379,0.2965897,0.0008941384,0.0002091262,0.0002999071,0.001282783,0.00025989,0.001845374],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.01976964,"threshold_uncertainty_score":0.1045531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0278452903490037,"score_gpt":0.354857906960524,"score_spread":0.3270126166115203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}