{"id":"W4411377735","doi":"10.1111/jdv.20777","title":"Systemic exposure and bioavailability of delgocitinib cream in adults with moderate to severe Chronic Hand Eczema","year":2025,"lang":"en","type":"article","venue":"Journal of the European Academy of Dermatology and Venereology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada); Probity Medical Research; Queen's University","funders":"LEO Pharma","keywords":"Medicine; Bioavailability; Pharmacokinetics; Oral administration; Drug; Area under the curve; Pharmacology; Dermatology; Gastroenterology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008284217,0.0002108065,0.0005658145,0.0001286324,0.0001468663,0.0003078264,0.0001205749,0.0003528717,0.001295344],"category_scores_gemma":[0.0009091807,0.0001204262,0.0002605894,0.0001209148,0.0001366932,0.0002099784,0.0001641723,0.0004088056,0.000218914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002771888,"about_ca_system_score_gemma":0.0002092018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004481928,"about_ca_topic_score_gemma":0.0009258303,"domain_scores_codex":[0.9996314,0.0001188732,0.00003710814,0.00007918208,0.00008740234,0.00004608358],"domain_scores_gemma":[0.9995257,0.0001503032,0.0001776353,0.00002050606,0.00005341367,0.00007254282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1871464,0.009412218,0.2754068,0.001655147,0.001033015,0.001210572,0.0007158879,0.001707261,0.3035185,0.00009386252,0.001975831,0.2161246],"study_design_scores_gemma":[0.01271623,0.2893819,0.6462888,0.0001054996,0.001053225,0.003844419,0.0003270386,0.002410769,0.03902836,0.00008636083,0.004719312,0.00003811172],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998264,0.001085579,0.0001153581,0.00003141901,0.000004793759,0.00007161919,0.00009457421,0.000005780117,0.0003268923],"genre_scores_gemma":[0.9993038,0.0001853957,0.0001704912,0.00004900996,0.00001006998,0.00004003293,0.00008951508,0.000001178827,0.0001503312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001295344,"threshold_uncertainty_score":0.00438112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00836640342736458,"score_gpt":0.2522171540528751,"score_spread":0.2438507506255106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}