{"id":"W4411382297","doi":"10.1038/s41467-025-60628-1","title":"Monoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Autoimmune Neurological Disorders and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"AXYS Technologies (Canada)","funders":"Astellas Pharma","keywords":"NMDA receptor; Autoantibody; Internalization; Medicine; Anti-NMDA receptor encephalitis; Encephalitis; Marmoset; Immunology; Monoclonal antibody; Antibody; Pharmacology; Receptor; Virology; Biology; Internal medicine; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000109736,0.0001615892,0.0003039021,0.0001062881,0.0004377872,0.00002655325,0.0004757794,0.0002515599,0.00006977415],"category_scores_gemma":[0.0001717459,0.0001294011,0.000182647,0.0002995589,0.0001236073,0.00004534565,0.0001553857,0.0005825789,0.0000097881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004170848,"about_ca_system_score_gemma":0.0000818366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002022936,"about_ca_topic_score_gemma":0.000008483168,"domain_scores_codex":[0.9990814,0.0000761121,0.0002672627,0.0002500191,0.0001200081,0.0002052061],"domain_scores_gemma":[0.9981655,0.000331348,0.00008953365,0.001178183,0.0001940506,0.00004141795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001732565,0.012345,0.4614984,0.0001889671,0.002712345,0.000007188547,0.0008080507,0.00001591113,0.1233776,0.1801133,0.03866071,0.17854],"study_design_scores_gemma":[0.006603842,0.0004287629,0.4329714,0.0001325275,0.0001297253,0.000004401021,0.00009551906,0.0005579204,0.002455308,0.001978659,0.554423,0.000218875],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.905055,0.04647868,0.001166377,0.03414755,0.0006336485,0.002735073,0.0001191132,0.0003121357,0.009352431],"genre_scores_gemma":[0.9800286,0.007897506,0.007238757,0.003070494,0.00003370527,0.0002317615,0.0005852387,0.00001673083,0.0008972379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5157623,"threshold_uncertainty_score":0.5276825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03376051289706809,"score_gpt":0.3818133943018658,"score_spread":0.3480528814047977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}