{"id":"W4411393326","doi":"10.1016/j.celrep.2025.115870","title":"The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy","year":2025,"lang":"en","type":"article","venue":"Cell Reports","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trent University; Dalhousie University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of Tsukuba; Universität zu Köln; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Autophagy; Cell biology; Biology; Dictyostelium; Dictyostelium discoideum; RNA splicing; Autophagosome; Lysosome; Alternative splicing; BAG3; ATG8; Gene; Exon; Genetics; RNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001068847,0.000184272,0.0001307606,0.0001865782,0.0001750973,0.0002033227,0.0001624702,0.0003061076,0.0004529991],"category_scores_gemma":[0.0001100353,0.0001066683,0.0001139274,0.000101379,0.0003199095,0.0001581794,0.0002245236,0.0002619982,0.0001774963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002171735,"about_ca_system_score_gemma":0.0001841259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002194121,"about_ca_topic_score_gemma":0.0002493112,"domain_scores_codex":[0.9999267,0.00001203097,0.000004974776,0.00002451769,0.00001937123,0.00001234306],"domain_scores_gemma":[0.999946,0.00000596712,0.00002219072,0.00000824894,0.000007340062,0.00001022593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005232712,0.000005434882,0.0008693427,0.0000171551,0.000004246032,0.000201727,0.0000113336,0.00006910462,0.9960485,0.0002412195,0.00002814788,0.002451391],"study_design_scores_gemma":[0.00002861216,0.0003836798,0.05989031,0.00001663769,0.0000343155,0.004043804,0.000089751,0.002481452,0.9243679,0.0009166237,0.007729078,0.00001793336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918953,0.001705974,0.00464748,0.0001037433,0.00001797638,0.00001529651,0.000121842,0.0001193047,0.001373175],"genre_scores_gemma":[0.996349,0.0004496911,0.002216277,0.00003151843,0.000005047375,0.00001130269,0.0001438798,0.000009085465,0.0007842482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004529991,"threshold_uncertainty_score":0.001575708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01072343763226603,"score_gpt":0.2548496984679757,"score_spread":0.2441262608357097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}