{"id":"W4411394543","doi":"10.1016/j.ard.2025.06.020","title":"POS0659 EFFICACY, SAFETY AND IMMUNOGENICITY OF THE PROPOSED TOCILIZUMAB BIOSIMILAR RGB-19, INTRAVENOUSLY ADMINISTERED TO PARTICIPANTS WITH ACTIVE RHEUMATOID ARTHRITIS: WEEK 24 DATA FROM A PHASE 3 STUDY","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Medicine; Biosimilar; Tocilizumab; Immunogenicity; Rheumatoid arthritis; Pharmacology; Immunology; Internal medicine; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005215912,0.0002956028,0.0008417165,0.00006556945,0.0003053231,0.00003108647,0.001265947,0.0001148899,0.000155476],"category_scores_gemma":[0.001693735,0.0001581908,0.0001671545,0.0004090882,0.0007725242,0.00009349806,0.001076224,0.0002047819,0.00000409641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001642515,"about_ca_system_score_gemma":0.000356578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004853958,"about_ca_topic_score_gemma":0.0002991331,"domain_scores_codex":[0.9971021,0.00101764,0.0008229712,0.0005078126,0.0001488298,0.0004006125],"domain_scores_gemma":[0.9968001,0.0008419471,0.0004110371,0.001701058,0.0001566457,0.00008923445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1212451,0.07539288,0.04218906,0.001404138,0.03678327,0.00003356815,0.01686879,0.0000448862,0.03731119,0.001371979,0.02183325,0.6455219],"study_design_scores_gemma":[0.030045,0.007406262,0.6946745,0.007712558,0.002635476,0.00002482396,0.01218855,0.0001859396,0.2384395,0.003196092,0.002428061,0.001063264],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838598,0.005724841,0.0001031509,0.004124259,0.0002364225,0.001840697,0.004040916,0.00002468538,0.00004519391],"genre_scores_gemma":[0.9983816,0.0006696284,0.0001483808,0.0006099252,0.00000392603,0.00002304676,0.00004752843,0.00001437053,0.0001016078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6524854,"threshold_uncertainty_score":0.6450835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09250792226928192,"score_gpt":0.3679126803776471,"score_spread":0.2754047581083652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}