{"id":"W4411395305","doi":"10.1016/j.ard.2025.05.874","title":"POS0492 A SINGLE INTRA-ARTICULAR INJECTION OF THE GENE THERAPY PCRX-201 WAS SAFE AND PROVIDED SUSTAINED CLINICAL BENEFITS FOR PATIENTS WITH MODERATE-TO-SEVERE KNEE OSTEOARTHRITIS THROUGH 3 YEARS","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Osteoarthritis; Intra articular; Genetic enhancement; Physical therapy; Surgery; Internal medicine; Alternative medicine; Pathology; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005511246,0.0004946551,0.001132136,0.0001902857,0.0002317255,0.000492375,0.0003104648,0.0007937957,0.006590146],"category_scores_gemma":[0.0004870974,0.0002014691,0.0004021406,0.0002196943,0.0005660251,0.0005291639,0.0001855708,0.001474597,0.0009642444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002570851,"about_ca_system_score_gemma":0.0006844877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002520144,"about_ca_topic_score_gemma":0.0008795027,"domain_scores_codex":[0.9998133,0.0000529415,0.00001734527,0.00003965475,0.00003835189,0.00003841005],"domain_scores_gemma":[0.9997873,0.00004338867,0.00005830944,0.00001865978,0.00001948394,0.00007304602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5559289,0.06167796,0.006525674,0.001790756,0.0006227162,0.0005171511,0.0002216747,0.0009926399,0.2141064,0.0005496143,0.004462135,0.1526044],"study_design_scores_gemma":[0.1211135,0.8474604,0.01232064,0.00007321452,0.0002466209,0.0004873045,0.00006662559,0.0005994245,0.01382593,0.0001642877,0.003608598,0.00003341256],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933082,0.00161412,0.0005205917,0.000219361,0.000162442,0.001031861,0.0009132191,0.00007574712,0.002154337],"genre_scores_gemma":[0.9940031,0.0007395666,0.000687018,0.0004215475,0.00009519531,0.0007540433,0.0009314446,0.00001171704,0.002356353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006590146,"threshold_uncertainty_score":0.02204627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03326681522957063,"score_gpt":0.3113873033508625,"score_spread":0.2781204881212918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}