{"id":"W4411395434","doi":"10.1016/j.ard.2025.06.321","title":"POS0966 OBINUTUZUMAB SHOWS PROMISE IN LUPUS NEPHRITIS REGARDLESS OF BASELINE SEROLOGICAL BIOMARKERS: AN EXPLORATORY POST HOC ANALYSIS OF THE PHASE II NOBILITY STUDY","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Medicine; Belimumab; Lupus nephritis; Obinutuzumab; Post-hoc analysis; Serology; Immunology; Internal medicine; Antibody; Rituximab; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01335861,0.001758011,0.003433891,0.0003149777,0.0004298628,0.001747788,0.001053456,0.001311035,0.005411984],"category_scores_gemma":[0.007384592,0.0004880855,0.005242193,0.0003785995,0.00129361,0.001460549,0.0008915696,0.002579805,0.0007426367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006288235,"about_ca_system_score_gemma":0.001247618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002815454,"about_ca_topic_score_gemma":0.0008156077,"domain_scores_codex":[0.9939228,0.004736566,0.0002218457,0.000429775,0.0002823258,0.0004066871],"domain_scores_gemma":[0.9931311,0.003612103,0.00110073,0.0008880673,0.0004039326,0.0008641527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9797782,0.003414207,0.003656756,0.0003302647,0.002730687,0.00006308343,0.00007251626,0.0004409706,0.003554212,0.0000693134,0.0004090493,0.005480883],"study_design_scores_gemma":[0.4456273,0.4905188,0.04572726,0.0001193521,0.008958318,0.0001954044,0.0001765477,0.001763606,0.002780335,0.0004946387,0.003568556,0.00006987219],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919136,0.00202886,0.0007142511,0.0003214544,0.0002067879,0.002034712,0.001082731,0.00004971772,0.001647832],"genre_scores_gemma":[0.9929462,0.0005488392,0.0008554919,0.0003696003,0.0002109928,0.001885944,0.001488393,0.00003143886,0.001662949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01335861,"threshold_uncertainty_score":0.0706479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05714294651728946,"score_gpt":0.3736485666210222,"score_spread":0.3165056201037328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}