{"id":"W4411395445","doi":"10.1016/j.ard.2025.06.147","title":"POS0788 BIMEKIZUMAB DEMONSTRATED SUSTAINED EFFICACY AND SAFETY ACROSS THE FULL SPECTRUM OF AXIAL SPONDYLOARTHRITIS: 3-YEAR RESULTS FROM TWO PHASE 3 STUDIES AND THEIR OPEN-LABEL EXTENSION","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Open label; Axial spondyloarthritis; Extension (predicate logic); Phase (matter); Physical therapy; Physical medicine and rehabilitation; Internal medicine; Adverse effect; Ankylosing spondylitis; Sacroiliitis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006653912,0.001295609,0.002198122,0.000414662,0.0005871634,0.001448426,0.0009400702,0.001593401,0.00294782],"category_scores_gemma":[0.002841819,0.0004838384,0.002529471,0.0005125676,0.0008132918,0.001266356,0.0005604503,0.003998882,0.0008033219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001063827,"about_ca_system_score_gemma":0.001752577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008494051,"about_ca_topic_score_gemma":0.001636637,"domain_scores_codex":[0.9981445,0.0008042205,0.00019919,0.0002170505,0.000371475,0.0002635507],"domain_scores_gemma":[0.9972484,0.0005670145,0.0008924024,0.000277343,0.0004450285,0.0005698975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5452713,0.05705023,0.02447512,0.002503294,0.005184144,0.0006141297,0.001008145,0.002695396,0.09236716,0.0004974332,0.00866907,0.2596647],"study_design_scores_gemma":[0.2008435,0.6833013,0.07923169,0.0002677449,0.003209424,0.001402173,0.0002196906,0.001761517,0.01741634,0.0003442586,0.01186389,0.0001385331],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783902,0.01133098,0.001814153,0.0007513777,0.0001918465,0.002149758,0.002446367,0.0001524927,0.002772831],"genre_scores_gemma":[0.9869263,0.00364207,0.001785901,0.001019902,0.0002092695,0.001366038,0.003641577,0.00004831087,0.001360681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006653912,"threshold_uncertainty_score":0.03518969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04968851757182446,"score_gpt":0.3794615808087261,"score_spread":0.3297730632369016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}