{"id":"W4411397747","doi":"10.1101/2025.06.17.25329750","title":"Essential information about chronobiology and chronotherapy for the optimal care of people with bipolar disorders: an international expert consensus","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of British Columbia; Ottawa Hospital; McGill University","funders":"Cilag; Medical Research Council; Idorsia Pharmaceuticals; H. Lundbeck A/S; Vancouver Coastal Health Research Institute; Leading Edge Endowment Fund; ZonMw; Mitacs; Michael Smith Health Research BC; National Health and Medical Research Council; University of Cambridge; National Institute of Mental Health; LivaNova; Jazz Pharmaceuticals; Wellcome Trust; Fondation Brain Canada; Fondation FondaMental; Canadian Network for Mood and Anxiety Treatments; Canadian Institutes of Health Research; Grand Challenges Canada; Sunovion; Sanofi","keywords":"Chronotherapy (sleep phase); Chronobiology; Medicine; Intensive care medicine; Circadian rhythm; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.09231951,0.001070263,0.001635069,0.005225393,0.003164995,0.003317838,0.003278068,0.005691563,0.005289941],"category_scores_gemma":[0.100867,0.0008416092,0.002856098,0.003104184,0.002303598,0.005621604,0.008458123,0.00642032,0.001922956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005053821,"about_ca_system_score_gemma":0.03647641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003820721,"about_ca_topic_score_gemma":0.004978456,"domain_scores_codex":[0.9464022,0.02832888,0.01332985,0.001617771,0.007863001,0.002458239],"domain_scores_gemma":[0.8866678,0.04298613,0.008561696,0.002469587,0.04860498,0.01070977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003960159,0.0003970728,0.01368181,0.02796036,0.0003226456,0.001951542,0.05344629,0.0009462204,0.005546138,0.009442981,0.2956744,0.5902345],"study_design_scores_gemma":[0.0004217279,0.0007259728,0.03776986,0.1328372,0.0006496971,0.004300771,0.1213195,0.003695096,0.001949961,0.03861294,0.6572037,0.0005136867],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.06799766,0.08832921,0.06365551,0.6806248,0.02774009,0.01514244,0.003177526,0.0004500941,0.05288272],"genre_scores_gemma":[0.4392515,0.1226792,0.2955254,0.09391273,0.008377844,0.018322,0.007741227,0.0003324953,0.01385766],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.09231951,"threshold_uncertainty_score":0.4882381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163650144502023,"score_gpt":0.2767096934499975,"score_spread":0.2650731920049773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}