{"id":"W4411401262","doi":"10.1016/j.ard.2025.05.708","title":"POS0321 KIDNEY-RELATED OUTCOMES WITH OBINUTUZUMAB IN PATIENTS WITH ACTIVE LUPUS NEPHRITIS: A PRE-SPECIFIED EXPLORATORY ANALYSIS OF THE REGENCY STUDY","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Medicine; Lupus nephritis; Obinutuzumab; Nephritis; Internal medicine; Immunology; Rituximab; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0144773,0.001191901,0.002260513,0.00038447,0.0003030066,0.001408263,0.000766601,0.0009082414,0.002359789],"category_scores_gemma":[0.00750278,0.0003368629,0.007641443,0.0006728278,0.0004685612,0.0007585609,0.001154512,0.001546689,0.0003787395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005734406,"about_ca_system_score_gemma":0.001061551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004558907,"about_ca_topic_score_gemma":0.001030574,"domain_scores_codex":[0.992789,0.005510795,0.0003307743,0.0004910756,0.0005093096,0.0003691024],"domain_scores_gemma":[0.9921938,0.003715025,0.002018753,0.00106907,0.0003717738,0.0006315708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6641182,0.001844579,0.2535689,0.002800917,0.03462603,0.0006938538,0.0002605079,0.005411484,0.003451702,0.0007487534,0.002820136,0.02965498],"study_design_scores_gemma":[0.07738253,0.1226919,0.7498743,0.0004644887,0.0264548,0.001284845,0.0002547619,0.008833196,0.002267177,0.001399808,0.008947838,0.0001443417],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863571,0.006805778,0.0008203032,0.0002631133,0.00006069425,0.0006116664,0.003460615,0.0000302412,0.001590468],"genre_scores_gemma":[0.9930901,0.0005647353,0.0008966354,0.0002456721,0.0001223594,0.0005975725,0.003824241,0.00001497924,0.0006436859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0144773,"threshold_uncertainty_score":0.07656419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0189231890720719,"score_gpt":0.2999134864998287,"score_spread":0.2809902974277568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}