{"id":"W4411403650","doi":"10.20944/preprints202506.0351.v2","title":"Recombinant IgG1 Fc-μTP-L309C Ameliorates Endogenous Rheumatoid Arthritis in the K/BxN Mouse Model by Decreasing Th1 and Th17 Cells in the Spleen, Lymph Nodes and Joint and Increasing T Regulatory Cells and IL-10 in the Joint","year":2025,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Blood Services; CSL Behring","keywords":"FOXP3; Arthritis; Rheumatoid arthritis; Synovial fluid; Spleen; Immunology; Chemistry; Inflammatory arthritis; IL-2 receptor; Flow cytometry; Lymph; Molecular biology; Cancer research; Medicine; T cell; Pathology; Biology; Immune system; Osteoarthritis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001702959,0.0006342597,0.0004401195,0.0004297311,0.0001776552,0.0001705238,0.0002892574,0.0004161383,0.002436172],"category_scores_gemma":[0.00005866361,0.0001316672,0.0003062323,0.0002077975,0.0002851379,0.0001504931,0.000108982,0.0008197321,0.0007071772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003352402,"about_ca_system_score_gemma":0.0003080175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001461484,"about_ca_topic_score_gemma":0.001644964,"domain_scores_codex":[0.9997568,0.00002222045,0.00002665871,0.00004373648,0.00008293191,0.0000676155],"domain_scores_gemma":[0.9999022,0.000006463525,0.00003475545,0.00001026219,0.0000122192,0.00003388425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003198561,0.0001101566,0.0001182211,0.00007882962,0.000006684988,0.00003777417,0.000007973204,0.00006931934,0.9976677,0.00002085206,0.0001292195,0.001433425],"study_design_scores_gemma":[0.0001195885,0.001537024,0.002973453,0.00001534075,0.00002826839,0.0003124075,0.00001850128,0.0004009188,0.992044,0.0000223816,0.002521995,0.00000613154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896224,0.00295639,0.003112674,0.0003629923,0.0001275829,0.00009171495,0.001212427,0.0004671064,0.002046764],"genre_scores_gemma":[0.9864266,0.002032992,0.002756064,0.0001753352,0.00004923037,0.000126706,0.00114385,0.00003729861,0.007251922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002436172,"threshold_uncertainty_score":0.008149743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1037229733998088,"score_gpt":0.3135438081423445,"score_spread":0.2098208347425357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}