{"id":"W4411403951","doi":"10.1016/j.bioadv.2025.214394","title":"Cationic lipopolymer based siRNA delivery for experimental lung cancer treatment","year":2025,"lang":"en","type":"article","venue":"Biomaterials Advances","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Small interfering RNA; Survivin; RNA interference; Cell; Gene silencing; Chemistry; Lung cancer; Cancer research; Apoptosis; RNA; Biology; Medicine; Biochemistry; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003700604,0.0001524545,0.0001466945,0.00004201773,0.00010164,0.00003872597,0.00011708,0.00007420243,0.00007343801],"category_scores_gemma":[0.000007652158,0.0001294464,0.00008816313,0.00004217139,0.00004509535,0.000008657669,0.00002717384,0.000004596758,0.000003156125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005082558,"about_ca_system_score_gemma":0.0001338908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001237184,"about_ca_topic_score_gemma":0.00007125403,"domain_scores_codex":[0.9992675,0.00002433762,0.0001840052,0.000298401,0.00004526833,0.0001805157],"domain_scores_gemma":[0.9996444,0.00001032994,0.00006629945,0.000192045,0.00005669823,0.00003023204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002847302,0.0000816609,0.0004675019,0.00003183321,0.00007302687,3.715172e-7,0.00001249118,0.0000392586,0.9938157,0.00002704642,0.001291931,0.003874515],"study_design_scores_gemma":[0.0007028269,0.0002751401,0.0001484815,0.00003390308,0.00003221352,4.299082e-7,0.00004229061,0.00009310215,0.9541938,0.00001348564,0.04432627,0.0001380132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.967836,0.02930885,0.0009202812,0.0001411958,0.001078656,0.0003554022,0.00016501,0.00001791317,0.0001766486],"genre_scores_gemma":[0.9958127,0.001220641,0.0004499251,0.0003152069,0.0002539988,0.0006337918,0.0002103787,0.0000120348,0.001091381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04303434,"threshold_uncertainty_score":0.5278672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01144249731761108,"score_gpt":0.3321631456978283,"score_spread":0.3207206483802172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}