{"id":"W4411407954","doi":"10.1016/j.neuron.2025.05.026","title":"New players in the leptin orchestra: PNOC/NPY neurons tune appetite and obesity","year":2025,"lang":"en","type":"article","venue":"Neuron","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Diabetes Canada; Canadian Institutes of Health Research; Université Laval","keywords":"Leptin; Anorectic; Appetite; Neuroscience; Hypothalamus; GABAergic; Energy homeostasis; Neuropeptide Y receptor; Energy expenditure; Food intake; Endocrinology; Obesity; Internal medicine; Biology; Medicine; Psychology; Neuropeptide; Inhibitory postsynaptic potential","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003020018,0.0003161918,0.0004081457,0.0002294625,0.0004517458,0.001350858,0.0004225129,0.0006950155,0.002177412],"category_scores_gemma":[0.000313303,0.0001937345,0.0002791574,0.0001600787,0.001105457,0.001955946,0.001109944,0.001234551,0.0002517051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005419666,"about_ca_system_score_gemma":0.0004453078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009656804,"about_ca_topic_score_gemma":0.002725936,"domain_scores_codex":[0.9998529,0.00001011625,0.000005889061,0.00003567159,0.00004443637,0.00005095345],"domain_scores_gemma":[0.9999226,0.000009831418,0.000008553037,0.000006227246,0.0000170902,0.00003572866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001212974,0.00006306763,0.006967182,0.0002884225,0.00007454265,0.0009927189,0.0007446865,0.0009370726,0.8863565,0.03108814,0.002368993,0.06890577],"study_design_scores_gemma":[0.0004502888,0.001105059,0.1858192,0.0007974419,0.0002918013,0.00412392,0.009025242,0.0221191,0.4545129,0.1205033,0.2010352,0.000216545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9052375,0.039832,0.02446696,0.007979939,0.001180885,0.00003248797,0.0002927204,0.0002432897,0.02073414],"genre_scores_gemma":[0.9648165,0.01261596,0.00817534,0.001355594,0.0004772579,0.00003172637,0.0001237414,0.000102225,0.01230168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002177412,"threshold_uncertainty_score":0.007284164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02137435925244395,"score_gpt":0.2645127291773707,"score_spread":0.2431383699249267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}