{"id":"W4411410479","doi":"10.1016/j.ard.2025.06.760","title":"POS1412 SINGLE-CELL ANALYSIS REVEALS THE PHENOTYPIC AND FUNCTIONAL HETEROGENEITY OF PERIPHERAL HELPER T CELLS IN THE SYNOVIUM OF RHEUMATOID ARTHRITIS","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Medicine; Rheumatoid arthritis; Phenotype; Immunology; Arthritis; Peripheral; Synovial membrane; Internal medicine; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002165302,0.0002511001,0.0003758284,0.0003757748,0.000478109,0.0004916539,0.000265457,0.000582592,0.003480262],"category_scores_gemma":[0.0001810412,0.0001976015,0.0003396913,0.0002980434,0.0002541145,0.0001883356,0.0002672677,0.0005636491,0.00157878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000187926,"about_ca_system_score_gemma":0.0002354409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000821699,"about_ca_topic_score_gemma":0.00193217,"domain_scores_codex":[0.9997746,0.00001781647,0.00001768309,0.000084864,0.00005460369,0.00005044702],"domain_scores_gemma":[0.9998748,0.00002243011,0.00001597069,0.00001663636,0.00003353638,0.00003659572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004051966,0.00002238475,0.004890143,0.0001212349,0.00001453423,0.0001193785,0.00007322543,0.0001154271,0.9894013,0.00007861367,0.000650789,0.004107988],"study_design_scores_gemma":[0.0001780679,0.0009148059,0.2552084,0.00007669926,0.0001833843,0.002344806,0.0008791446,0.008766095,0.7097394,0.0007484606,0.02087864,0.00008210701],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775957,0.001988433,0.009399086,0.0002322751,0.0001381434,0.00006066729,0.007694824,0.0003272357,0.002563776],"genre_scores_gemma":[0.9730162,0.0009669016,0.01039181,0.0007638535,0.00006244805,0.0002003625,0.01000394,0.0001571698,0.004437304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003480262,"threshold_uncertainty_score":0.01164263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0364739386641306,"score_gpt":0.3002609989303248,"score_spread":0.2637870602661941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}