{"id":"W4411410596","doi":"10.1016/j.ard.2025.06.1258","title":"ABS0448 ZASOCITINIB (TAK-279), AN ORAL, ALLOSTERIC, SELECTIVE TYK2 INHIBITOR, IN MODERATE-TO-SEVERE PLAQUE PSORIASIS: EFFICACY ANALYSIS BY BASELINE CHARACTERISTICS FROM A RANDOMISED PHASE 2B TRIAL","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"","keywords":"Medicine; Plaque psoriasis; Psoriasis; Internal medicine; Randomized controlled trial; Clinical trial; Pharmacology; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004213025,0.001645561,0.002859196,0.0005929812,0.0003710446,0.0008322246,0.0007836235,0.001080027,0.006717267],"category_scores_gemma":[0.002394899,0.0006495252,0.002659688,0.0006908344,0.0009215723,0.0007048475,0.0004082496,0.002195642,0.00100531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007208724,"about_ca_system_score_gemma":0.001245342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004684538,"about_ca_topic_score_gemma":0.001273257,"domain_scores_codex":[0.9982322,0.0009858973,0.0001487793,0.0002283621,0.0002561808,0.0001486479],"domain_scores_gemma":[0.9985703,0.0003900083,0.0004018485,0.000105598,0.0001221618,0.0004099881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9715105,0.003801948,0.001700932,0.0005864684,0.001543612,0.00003251068,0.00004021876,0.0004276684,0.005405445,0.00006045,0.0006671812,0.01422313],"study_design_scores_gemma":[0.9099803,0.07835289,0.008576322,0.00002886514,0.00120345,0.00007070575,0.00001468646,0.0004271298,0.0004791985,0.0001060531,0.0007405321,0.00001989262],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855682,0.006101298,0.0008159413,0.00046252,0.0002712687,0.002847046,0.001951643,0.00009419929,0.001887838],"genre_scores_gemma":[0.9876506,0.002788377,0.001027326,0.0005034426,0.0005102098,0.003076292,0.002913884,0.00002615426,0.001503786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006717267,"threshold_uncertainty_score":0.02247149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02850258043770714,"score_gpt":0.314214772876351,"score_spread":0.2857121924386439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}