{"id":"W4411411094","doi":"10.1016/j.ard.2025.06.426","title":"POS1072 Icotrokinra, a Targeted Oral Peptide That Selectively Blocks the Interleukin-23-Receptor, for the Treatment of Moderate-to-Severe Plaque Psoriasis: Results Through Week 24 of the Phase 3, Randomized, Double-Blind, Placebo-Controlled ICONIC-LEAD Trial","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"","keywords":"Medicine; Plaque psoriasis; Psoriasis; Interleukin 23; Randomized controlled trial; Internal medicine; Dermatology; Gastroenterology; Interleukin; Cytokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001255083,0.0008475501,0.001257367,0.0001887901,0.0003456243,0.0008271616,0.0004595634,0.001204889,0.006038345],"category_scores_gemma":[0.001014086,0.0002752993,0.000987894,0.0003196104,0.0007393601,0.0007353293,0.0001992219,0.001976513,0.001134627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006506633,"about_ca_system_score_gemma":0.001030247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006230636,"about_ca_topic_score_gemma":0.001822965,"domain_scores_codex":[0.9995535,0.0002101031,0.00003268085,0.0000786834,0.00005026626,0.000074722],"domain_scores_gemma":[0.9994038,0.0001216705,0.0001369969,0.00004237148,0.00006212153,0.0002330787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9087697,0.006396731,0.001996029,0.001489796,0.0009003927,0.000124084,0.00008961029,0.0005475741,0.01358899,0.0003677457,0.006377291,0.05935212],"study_design_scores_gemma":[0.8817062,0.1063191,0.005403168,0.0001077766,0.0007012369,0.0002048126,0.0000377049,0.00042178,0.001759302,0.0002089074,0.00310472,0.00002523992],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974183,0.01024217,0.000862452,0.001054715,0.000469217,0.002673184,0.002314034,0.0002450862,0.007956161],"genre_scores_gemma":[0.9870762,0.003447175,0.0008850853,0.001476973,0.0002762655,0.001675885,0.002463479,0.00003823984,0.002660591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006038345,"threshold_uncertainty_score":0.02020025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06217196332027962,"score_gpt":0.323081874671518,"score_spread":0.2609099113512384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}