{"id":"W4411412184","doi":"10.1016/j.ccell.2025.06.002","title":"Large B cell lymphoma microenvironment archetype profiles","year":2025,"lang":"en","type":"article","venue":"Cancer Cell","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Spinal Cord Injury BC","funders":"National Cancer Institute; Leukemia and Lymphoma Society; Lymphoma Research Foundation","keywords":"Lymphoma; Cancer research; Tumor microenvironment; Archetype; Biology; Cell biology; Computational biology; Medicine; Immunology; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001153881,0.000164539,0.0001522476,0.0007633527,0.0002224668,0.0004088401,0.0001016794,0.0001687169,0.001266424],"category_scores_gemma":[0.0001455455,0.00009474335,0.0001208538,0.0003358366,0.0001887751,0.000189837,0.0004001521,0.000186847,0.0003078499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001959852,"about_ca_system_score_gemma":0.0001103059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005451353,"about_ca_topic_score_gemma":0.001374478,"domain_scores_codex":[0.9998564,0.00002030444,0.000008478497,0.00004216685,0.00003530296,0.00003739116],"domain_scores_gemma":[0.9999058,0.00001354018,0.00003158325,0.00001475181,0.00001399412,0.00002036572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000436555,0.00001867888,0.03911886,0.00004451255,0.0000194658,0.0002602668,0.0001604467,0.0001620169,0.9526717,0.0001898957,0.00007401011,0.006843537],"study_design_scores_gemma":[0.00003515029,0.0004244896,0.5471876,0.00002096167,0.00008512964,0.007646543,0.001050888,0.002197436,0.4330435,0.0008354998,0.007451233,0.00002161164],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959115,0.0003598855,0.00233259,0.00001382184,0.000001457879,0.00002370334,0.0004401913,0.00004636592,0.0008705741],"genre_scores_gemma":[0.9973085,0.0001772766,0.001330196,0.00002330289,0.000002137222,0.00002760283,0.0006205047,0.00001371332,0.0004967146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001266424,"threshold_uncertainty_score":0.004236579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01600798319119411,"score_gpt":0.3006595645842687,"score_spread":0.2846515813930746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}