{"id":"W4411412222","doi":"10.1016/j.ard.2025.05.029","title":"OP0006 OBINUTUZUMAB DEMONSTRATES CONSISTENT BENEFIT ACROSS NUMEROUS PRIMARY ENDPOINT DEFINITIONS USING REGENCY STUDY RESULTS OF PATIENTS WITH ACTIVE LUPUS NEPHRITIS","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Medicine; Obinutuzumab; Lupus nephritis; Clinical endpoint; Systemic lupus erythematosus; Immunology; Internal medicine; Clinical trial; Rituximab; Lymphoma; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01378065,0.0008379762,0.002270594,0.0006589376,0.0003497269,0.001752055,0.0004796162,0.0005368883,0.002651087],"category_scores_gemma":[0.01197792,0.0001946212,0.002696086,0.0006375293,0.0005714189,0.0008581823,0.0009033594,0.001844893,0.0004547988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005819796,"about_ca_system_score_gemma":0.0008798531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005204706,"about_ca_topic_score_gemma":0.001225629,"domain_scores_codex":[0.9940349,0.003345462,0.0005030307,0.0008033906,0.001012018,0.0003011893],"domain_scores_gemma":[0.9908606,0.00382343,0.003191833,0.000932257,0.0006901502,0.0005017316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4255027,0.003399197,0.3055141,0.003339498,0.01466871,0.0002833207,0.000573359,0.004284098,0.01647898,0.000750631,0.01301131,0.2121942],"study_design_scores_gemma":[0.03612224,0.06631465,0.8362054,0.0007014995,0.01221695,0.001461111,0.0002536431,0.006724393,0.01352488,0.00141129,0.02489503,0.0001689595],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739125,0.01198645,0.001920031,0.0006428152,0.0001807317,0.0003557161,0.003561514,0.0001767541,0.00726348],"genre_scores_gemma":[0.9937785,0.0007521774,0.001177192,0.0003164009,0.0001416098,0.0001708438,0.002981173,0.00003926234,0.000642812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01378065,"threshold_uncertainty_score":0.07287991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.053759055397508,"score_gpt":0.3283428539714713,"score_spread":0.2745837985739633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}