{"id":"W4411412999","doi":"10.1021/acsomega.5c02108","title":"Unlocking Histatin Potential against <i>Candida albicans</i> and <i>Streptococcus mutans</i> Biofilms: Targeting the Extracellular Matrix While Preserving Oral Cell Integrity","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Streptococcus mutans; Biofilm; Candida albicans; Microbiology; Extracellular matrix; Chemistry; Biology; Bacteria; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004311862,0.0003155458,0.0003729464,0.0001025052,0.0007788479,0.0001439391,0.0004408099,0.0002733126,0.00009896774],"category_scores_gemma":[0.00008309911,0.0002424823,0.0001126399,0.0002807753,0.0004378826,0.0002295103,0.0004102208,0.0008156039,0.00003070727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005278781,"about_ca_system_score_gemma":0.0001169197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007563387,"about_ca_topic_score_gemma":0.00007830097,"domain_scores_codex":[0.9982132,0.0002514425,0.0004295724,0.0004704955,0.00005487266,0.0005804677],"domain_scores_gemma":[0.9990774,0.0002441979,0.0001955063,0.0003571661,0.00009605916,0.00002965231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007611851,0.00008116777,0.002287549,0.00008703476,0.0001035796,0.00001602365,0.0004331935,0.00005437753,0.955063,0.0004670145,0.03930975,0.002021126],"study_design_scores_gemma":[0.001930901,0.0001051651,0.0005389231,0.0002356661,0.0001895291,0.0000242846,0.005220735,0.0001643557,0.6781945,0.0003178611,0.3124605,0.0006175971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980226,0.01342882,0.0007423091,0.001590739,0.0007165222,0.0004748992,0.0001186431,0.0001271774,0.002574876],"genre_scores_gemma":[0.983988,0.0002409015,0.000355404,0.000482556,0.00005854897,0.0000274482,0.0001397431,0.00002630638,0.01468112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2768686,"threshold_uncertainty_score":0.9888141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008151762567050072,"score_gpt":0.2275890351840473,"score_spread":0.2194372726169972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}