{"id":"W4411412999","doi":"10.1021/acsomega.5c02108","title":"Unlocking Histatin Potential against <i>Candida albicans</i> and <i>Streptococcus mutans</i> Biofilms: Targeting the Extracellular Matrix While Preserving Oral Cell Integrity","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Streptococcus mutans; Biofilm; Candida albicans; Microbiology; Extracellular matrix; Chemistry; Biology; Bacteria; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001377504,0.0002517709,0.0001417193,0.00007820308,0.00008381162,0.0002017776,0.00014023,0.0002363435,0.0005415412],"category_scores_gemma":[0.00008450435,0.00007614974,0.0002227755,0.00006560519,0.000149091,0.0001682948,0.0001527966,0.000299511,0.0001098463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001078671,"about_ca_system_score_gemma":0.0001460715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002224509,"about_ca_topic_score_gemma":0.0003740701,"domain_scores_codex":[0.9999212,0.00001574762,0.000006629802,0.00001412219,0.0000240287,0.0000182008],"domain_scores_gemma":[0.9999355,0.00001013316,0.00002431776,0.000005127606,0.00001265,0.00001228848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000395805,0.00001577024,0.0001038464,0.00003454035,0.000003057437,0.00001082658,0.000005231005,0.00002550927,0.9984294,0.00001715716,0.00000832921,0.001306752],"study_design_scores_gemma":[0.000005745676,0.0004256834,0.002054942,0.00000534112,0.00001657314,0.0001198689,0.00001933382,0.0001586331,0.9963906,0.000009395346,0.0007913898,0.000002472106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967828,0.001153222,0.001360728,0.00003189538,0.00001191203,0.00001893004,0.00004649087,0.00001439881,0.0005796879],"genre_scores_gemma":[0.995496,0.0007233851,0.002904174,0.00005902304,0.000004635726,0.0000116024,0.00009917671,0.000006258854,0.0006956676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005415412,"threshold_uncertainty_score":0.001811624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008151762567050072,"score_gpt":0.2275890351840473,"score_spread":0.2194372726169972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}