{"id":"W4411413907","doi":"10.1016/j.ard.2025.06.1895","title":"ABS0857 PHARMACODYNAMIC EFFECTS OF OBINUTUZUMAB ON B CELLS AND SEROLOGICAL MARKERS IN PATIENTS WITH ACTIVE LUPUS NEPHRITIS: RESULTS FROM THE PHASE III REGENCY STUDY","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Medicine; Lupus nephritis; Obinutuzumab; Serology; Belimumab; Pharmacodynamics; Nephritis; Immunology; Internal medicine; Systemic lupus erythematosus; Antibody; Rituximab; B cell; Pharmacokinetics; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002275751,0.0007466421,0.001330226,0.0002321008,0.0002093519,0.0008683504,0.0004384924,0.0006967355,0.001475545],"category_scores_gemma":[0.00106599,0.0001790749,0.001331804,0.0002472164,0.0004567443,0.0003426663,0.0002279896,0.002232558,0.000467519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005545951,"about_ca_system_score_gemma":0.0007739039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004480648,"about_ca_topic_score_gemma":0.0009563924,"domain_scores_codex":[0.9994977,0.0002696344,0.00002992741,0.00005547349,0.0000789758,0.00006830361],"domain_scores_gemma":[0.9991973,0.0002133394,0.0001954101,0.00005396364,0.00009000449,0.0002498406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5387427,0.0424695,0.02212817,0.001784812,0.003911441,0.0004674329,0.0005252872,0.004036474,0.1028006,0.0003968794,0.007992199,0.2747445],"study_design_scores_gemma":[0.2290584,0.6673443,0.06939507,0.0001932742,0.002473626,0.0009495078,0.00009320476,0.00240369,0.01319669,0.0003471951,0.01448302,0.00006213188],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881003,0.007618909,0.0003868018,0.0004738924,0.00007267806,0.0005844456,0.000865282,0.00007500184,0.001822675],"genre_scores_gemma":[0.9911581,0.002746776,0.001016764,0.0009783944,0.0001621797,0.0005809978,0.001912146,0.00002474187,0.001419835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002275751,"threshold_uncertainty_score":0.01203549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01539676927004406,"score_gpt":0.3132327296140774,"score_spread":0.2978359603440333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}