{"id":"W4411415108","doi":"10.1016/j.ard.2025.06.510","title":"POS1160 A PHASE IB, MULTICENTRE, OPEN-LABEL, DOSE-ESCALATION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF SUBCUTANEOUSLY ADMINISTERED MOSUNETUZUMAB IN PARTICIPANTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Medicine; Pharmacokinetics; Pharmacodynamics; Tolerability; Pharmacology; Adverse effect; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00187114,0.001406445,0.00144316,0.0003291634,0.0004396157,0.000702934,0.0007296229,0.001316253,0.004840714],"category_scores_gemma":[0.001130034,0.0005723875,0.0008844854,0.0003327591,0.0007635317,0.0008337481,0.0003186873,0.002915744,0.001219094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007177048,"about_ca_system_score_gemma":0.001163979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004881406,"about_ca_topic_score_gemma":0.001280744,"domain_scores_codex":[0.999332,0.0003150182,0.00004235006,0.0001332894,0.00008694061,0.00009039824],"domain_scores_gemma":[0.9991599,0.0001216227,0.0002155225,0.00008412709,0.00007974281,0.0003392004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6972907,0.1026709,0.01437557,0.0007940637,0.001188113,0.0002709887,0.0002736004,0.002075486,0.1007991,0.0002295902,0.003526846,0.07650502],"study_design_scores_gemma":[0.2861723,0.6884067,0.01828485,0.00002513062,0.0002779371,0.0002583526,0.00003803298,0.0008938889,0.003611346,0.0001086549,0.001898137,0.00002472232],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935446,0.0006793212,0.0005804162,0.0001705246,0.00008230169,0.002529105,0.0009436519,0.00009715902,0.001372931],"genre_scores_gemma":[0.992403,0.000360048,0.001394496,0.0005476502,0.00007019092,0.001999823,0.00154637,0.00001627241,0.001662116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004840714,"threshold_uncertainty_score":0.01619375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0900225317181723,"score_gpt":0.433574201364452,"score_spread":0.3435516696462796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}