{"id":"W4411416439","doi":"10.1016/j.ard.2025.05.843","title":"POS0460 Pediatric ANCA-Associated Vasculitis Study of Avacopan Efficacy, Pharmacokinetics, and Safety: A Phase 3 Trial in Progress","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Vasculitis and related conditions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; SickKids Foundation; University of Toronto; BC Children's Hospital; Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Medicine; ANCA-Associated Vasculitis; Pharmacokinetics; Vasculitis; Clinical trial; Internal medicine; Intensive care medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003539692,0.001625216,0.00200551,0.0003606041,0.0005012639,0.001615152,0.001064935,0.002120776,0.007010188],"category_scores_gemma":[0.002006534,0.0004519827,0.00186084,0.0004881351,0.001079646,0.00138733,0.0005199235,0.0049719,0.001522696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009730337,"about_ca_system_score_gemma":0.001801884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005109887,"about_ca_topic_score_gemma":0.001231284,"domain_scores_codex":[0.9989167,0.0005634062,0.00006474881,0.0001454269,0.0001666768,0.0001429843],"domain_scores_gemma":[0.9987159,0.000244138,0.0003080582,0.00009019882,0.0001175832,0.0005240712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7151476,0.0514658,0.00826252,0.003187547,0.0048446,0.0008253381,0.0005457482,0.003655693,0.029827,0.00206997,0.02233021,0.157838],"study_design_scores_gemma":[0.7105509,0.2621682,0.007701281,0.0002126198,0.001088741,0.0009108391,0.00008705858,0.001709035,0.002164784,0.0008882312,0.01246786,0.00005046258],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9343321,0.02005723,0.003754495,0.004519235,0.001028633,0.01399316,0.00937826,0.0005344463,0.01240255],"genre_scores_gemma":[0.9421253,0.0100848,0.009505758,0.006092989,0.0009172913,0.01531489,0.00928271,0.0001462527,0.006530037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007010188,"threshold_uncertainty_score":0.02345145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02671039987681897,"score_gpt":0.3568133529890065,"score_spread":0.3301029531121875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}