{"id":"W4411417714","doi":"10.51731/cjht.2025.1147","title":"Durvalumab (Imfinzi) and Tremelimumab (Imjudo)","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Health Technologies","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Oncology; Chemotherapy; Durvalumab; Gemcitabine; Internal medicine; Lung cancer; Regimen; Immunotherapy; Cancer; Pembrolizumab","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004150051,0.00022442,0.0003401915,0.0004379913,0.0002949659,0.0004857514,0.0004683095,0.0005000372,0.008345776],"category_scores_gemma":[0.0007372919,0.0001135128,0.0004016679,0.0003419797,0.0002158097,0.000294306,0.0003412031,0.001124679,0.002300255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00238156,"about_ca_system_score_gemma":0.001963255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01303033,"about_ca_topic_score_gemma":0.0537156,"domain_scores_codex":[0.9997522,0.00002653286,0.00001916299,0.00003891169,0.000103034,0.00006007852],"domain_scores_gemma":[0.9996974,0.00002822808,0.00006100336,0.00001899955,0.00005972346,0.0001346698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003184285,0.0004437944,0.005836426,0.0006523754,0.0001772514,0.0007447995,0.00006691992,0.0005720627,0.018213,0.006920603,0.1055331,0.8576553],"study_design_scores_gemma":[0.003532318,0.001433009,0.02262793,0.0002377335,0.0001553469,0.004898552,0.00004080361,0.000845937,0.008789591,0.001228908,0.956179,0.00003081064],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.2625621,0.2591953,0.01007762,0.03312458,0.003292867,0.001365706,0.01244249,0.002050027,0.4158893],"genre_scores_gemma":[0.7785375,0.04146489,0.01410619,0.009916682,0.0008188517,0.0006093634,0.0124697,0.0001082784,0.1419685],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.01303033,"threshold_uncertainty_score":0.02791941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01595510999347823,"score_gpt":0.3390436323908056,"score_spread":0.3230885223973274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}