{"id":"W4411421244","doi":"10.1016/j.ard.2025.06.694","title":"POS1345 APREMILAST REDUCES MRI INFLAMMATION IN INDIVIDUAL JOINTS AND CLINICAL DACTYLITIS IN PATIENTS WITH PSORIATIC ARTHRITIS: DYNAMIC CONTRAST-ENHANCED MRI (DCE-MRI) RESULTS FROM THE PHASE 4 MOSAIC STUDY","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Dactylitis; Psoriatic arthritis; Apremilast; Dynamic contrast-enhanced MRI; Magnetic resonance imaging; Radiology; Dynamic contrast; Pathology; Psoriasis; Enthesitis; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001308766,0.0006795977,0.001348017,0.0002404436,0.0002410889,0.0005250273,0.0003699922,0.0006942403,0.003305412],"category_scores_gemma":[0.0007299164,0.0003004118,0.0008338431,0.0002710256,0.0004045177,0.0004679158,0.0002344159,0.001450142,0.0004903044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004073441,"about_ca_system_score_gemma":0.0005992939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002672827,"about_ca_topic_score_gemma":0.001126481,"domain_scores_codex":[0.99962,0.0001821442,0.00003516627,0.00005079963,0.00006846459,0.00004335792],"domain_scores_gemma":[0.9994608,0.0000899297,0.0001618934,0.00002967479,0.000047744,0.0002099468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7055492,0.03212254,0.0211213,0.001805019,0.002594976,0.0002930844,0.0001902506,0.001560377,0.08796573,0.0002128019,0.004607771,0.1419769],"study_design_scores_gemma":[0.323413,0.5915834,0.07268653,0.0001113798,0.001352335,0.0007794131,0.00008177383,0.001185881,0.005345499,0.0001917591,0.003218089,0.00005087224],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900498,0.006318655,0.0002140329,0.0003864345,0.00007687532,0.0005994884,0.0006758487,0.00004393943,0.00163499],"genre_scores_gemma":[0.9949906,0.001687382,0.0006749227,0.0005491203,0.0001634755,0.0004455671,0.0007931435,0.000008599972,0.0006871546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003305412,"threshold_uncertainty_score":0.01105767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02142679563925757,"score_gpt":0.3400606698779767,"score_spread":0.3186338742387191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}