{"id":"W4411422331","doi":"10.1016/j.ard.2025.06.246","title":"POS0891 REAL-WORLD EFFECTIVENESS OF UPADACITINIB ON EARLY PAIN CONTROL IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS: INTERIM RESULTS FROM THE UPSTAND OBSERVATIONAL STUDY","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Observational study; Interim; Interim analysis; Pain control; Physical therapy; Axial spondyloarthritis; Medical physics; Internal medicine; Randomized controlled trial; Ankylosing spondylitis; Surgery; Sacroiliitis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005962778,0.0008482085,0.002035419,0.0004099098,0.0006791992,0.001612221,0.0006652336,0.001259318,0.006034726],"category_scores_gemma":[0.007403449,0.0004132956,0.003654858,0.0007880905,0.0004307919,0.001373111,0.0009661926,0.002726933,0.001309932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006610999,"about_ca_system_score_gemma":0.001111199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008087511,"about_ca_topic_score_gemma":0.001943406,"domain_scores_codex":[0.9968092,0.001311597,0.0005173702,0.0004180543,0.000579854,0.0003639332],"domain_scores_gemma":[0.9907085,0.002129369,0.003804594,0.001068888,0.001266189,0.001022416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5922489,0.01427806,0.26046,0.003463561,0.01609923,0.0006056879,0.0004393212,0.002872153,0.004755664,0.000431951,0.01848872,0.08585668],"study_design_scores_gemma":[0.08655906,0.1925511,0.6823807,0.001039974,0.01447647,0.00119787,0.0004573728,0.002073416,0.002525974,0.0006070316,0.01588844,0.0002425026],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.949731,0.004812607,0.0009830098,0.0008658674,0.0003047108,0.001805799,0.03614191,0.00009994393,0.005255286],"genre_scores_gemma":[0.9493616,0.001514776,0.002284486,0.001039717,0.0006603916,0.00255323,0.04100148,0.00003233464,0.001552031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006034726,"threshold_uncertainty_score":0.03153455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04018969592126637,"score_gpt":0.3178221325848705,"score_spread":0.2776324366636041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}