{"id":"W4411426977","doi":"10.1016/j.ard.2025.05.172","title":"OP0151 UPREGULATION OF TYPE 1 INTERFERON STIMULATED GENES IN CIRCULATING INNATE IMMUNE CELLS PRECEDES THE ONSET OF SUBCLINICAL SYNOVITIS IN ANTI-CCP+ AT-RISK INDIVIDUALS WHO IMMINENTLY PROGRESS TO RHEUMATOID ARTHRITIS.","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Medicine; Rheumatoid arthritis; Immunology; Innate immune system; Subclinical infection; Synovitis; Interferon; Downregulation and upregulation; Immune system; Gene; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001391046,0.0001981997,0.000245634,0.0003790558,0.0001885362,0.0003334056,0.0001551802,0.0002728106,0.002954707],"category_scores_gemma":[0.0004588243,0.0001928528,0.0001778898,0.0002757822,0.0002101097,0.0001515899,0.0002160677,0.0003250145,0.0005081294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001380722,"about_ca_system_score_gemma":0.0001173311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007275219,"about_ca_topic_score_gemma":0.001094542,"domain_scores_codex":[0.9998814,0.00001361274,0.000008123625,0.00004252917,0.00002566477,0.0000286737],"domain_scores_gemma":[0.9996811,0.00005655253,0.0001399688,0.00002136603,0.00003167001,0.00006927665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003585555,0.0001220461,0.6684841,0.0001420501,0.00006653662,0.001106563,0.0003676813,0.0001159373,0.316287,0.00005776729,0.0004530839,0.009211629],"study_design_scores_gemma":[0.00001554,0.00033175,0.9941167,0.00000708056,0.00002142945,0.0009410849,0.0001549564,0.0001474454,0.003933555,0.00003287032,0.0002934558,0.000004220679],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990307,0.0001645617,0.0001258527,0.000014181,0.000004230046,0.000006866134,0.0004178967,0.000005766259,0.0002298111],"genre_scores_gemma":[0.9985286,0.00007321445,0.0002548582,0.00004046418,0.000006748045,0.00001905678,0.0005744206,0.000004998296,0.0004975571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002954707,"threshold_uncertainty_score":0.009884417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01618467260318693,"score_gpt":0.2881304086771032,"score_spread":0.2719457360739163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}