{"id":"W4411426977","doi":"10.1016/j.ard.2025.05.172","title":"OP0151 UPREGULATION OF TYPE 1 INTERFERON STIMULATED GENES IN CIRCULATING INNATE IMMUNE CELLS PRECEDES THE ONSET OF SUBCLINICAL SYNOVITIS IN ANTI-CCP+ AT-RISK INDIVIDUALS WHO IMMINENTLY PROGRESS TO RHEUMATOID ARTHRITIS.","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Medicine; Rheumatoid arthritis; Immunology; Innate immune system; Subclinical infection; Synovitis; Interferon; Downregulation and upregulation; Immune system; Gene; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008952261,0.0002311746,0.0007961777,0.000276652,0.0001363641,0.00001498119,0.0006753603,0.0001562021,0.00006978863],"category_scores_gemma":[0.0009424551,0.0001666077,0.0002247509,0.0008399737,0.0005821123,0.0001064141,0.0004307428,0.0002024117,0.000008465207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001883115,"about_ca_system_score_gemma":0.0001280426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008532917,"about_ca_topic_score_gemma":0.00004822451,"domain_scores_codex":[0.9969335,0.000779042,0.001554673,0.0002702794,0.0001158802,0.000346611],"domain_scores_gemma":[0.9976063,0.0007901469,0.0008012499,0.0006165318,0.0001760006,0.000009725204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001575456,0.002773249,0.7527109,0.001002079,0.001101217,0.000002024942,0.008048767,0.02019225,0.05884803,0.0005532729,0.0003020244,0.1528907],"study_design_scores_gemma":[0.001348954,0.0001832528,0.9143345,0.005305615,0.00004388499,0.00000227994,0.000916737,0.0004045398,0.07671097,0.0005363351,0.00004337014,0.0001695312],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.936304,0.0620872,0.000007965245,0.0003260851,0.0003061499,0.0007702464,0.0001611358,0.00001534331,0.00002187019],"genre_scores_gemma":[0.9960766,0.003697719,0.00001044241,0.00003440406,5.596613e-7,0.00003483832,0.00006888028,0.000014946,0.00006162404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1616236,"threshold_uncertainty_score":0.6794063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01618467260318693,"score_gpt":0.2881304086771032,"score_spread":0.2719457360739163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}