{"id":"W4411428627","doi":"10.1016/j.ard.2025.06.528","title":"POS1178 DRUG DISCONTINUATION IN INFLAMMATORY ARTHRITIS FOLLOWING MANDATORY NON-MEDICAL SWITCHING FROM ORIGINATOR TO BIOSIMILAR IN QUEBEC, CANADA","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke; Montreal Clinical Research Institute; McGill University Health Centre","funders":"","keywords":"Medicine; Biosimilar; Discontinuation; Drug; Arthritis; Drug approval; Rheumatoid arthritis; Intensive care medicine; Pharmacology; Dermatology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005103829,0.0001726816,0.0004555849,0.0001482524,0.00007369345,0.00002278183,0.0004483052,0.0001234831,0.0001780184],"category_scores_gemma":[0.001239364,0.0001264316,0.0001561765,0.0003153472,0.00007904581,0.0001007529,0.0001903198,0.0002270592,0.000004935772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006715892,"about_ca_system_score_gemma":0.0007808896,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.3435594,"about_ca_topic_score_gemma":0.7833185,"domain_scores_codex":[0.99829,0.0003693194,0.0006297958,0.0002596859,0.0001401178,0.0003110866],"domain_scores_gemma":[0.9988587,0.0005846179,0.0001192908,0.0003381972,0.00003485879,0.00006437246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004811569,0.001128466,0.5696889,0.0004134889,0.001097932,0.0001019213,0.001539787,0.00004356354,0.004387335,0.00214718,0.107811,0.3111593],"study_design_scores_gemma":[0.001998211,0.00002581988,0.9604015,0.008295126,0.00008385253,6.431998e-7,0.001045235,0.0001590072,0.01762569,0.002994841,0.006975688,0.0003944312],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795552,0.004746009,0.00005757465,0.01436453,0.0007899781,0.0002983597,0.00006868324,0.00001122239,0.000108392],"genre_scores_gemma":[0.9967691,0.0001551259,0.00004273941,0.002556867,0.00000888772,0.00002695497,0.00001381935,0.000008181957,0.0004183284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.439759,"threshold_uncertainty_score":0.6608119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007377121633257179,"score_gpt":0.277455790872275,"score_spread":0.2700786692390179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}