{"id":"W4411428667","doi":"10.1038/s41588-025-02227-w","title":"Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations","year":2025,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; Occupational Cancer Research Centre; University Health Network","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; National Heart, Lung, and Blood Institute; Fondation pour la Recherche sur Alzheimer; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; U.S. Department of Veterans Affairs; EU Joint Programme – Neurodegenerative Disease Research; Université de Lille; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease","keywords":"Biology; Polygenic risk score; Genome-wide association study; Apolipoprotein E; Genetic association; Disease; Genetics; Locus (genetics); Allele; Single-nucleotide polymorphism; Genotype; Gene; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01648274,0.0007854118,0.0008110606,0.001922657,0.0004953076,0.001115071,0.0008271178,0.0005641285,0.001389832],"category_scores_gemma":[0.04241955,0.000322741,0.001130219,0.001326373,0.0009236024,0.001005407,0.001997684,0.001075381,0.0001996971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004200962,"about_ca_system_score_gemma":0.0002237801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003858531,"about_ca_topic_score_gemma":0.002098997,"domain_scores_codex":[0.9900098,0.006784073,0.0004214068,0.002032914,0.0004621368,0.0002895701],"domain_scores_gemma":[0.9723733,0.0163072,0.002467404,0.007226329,0.00104553,0.0005802648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001656212,0.0001842854,0.8991313,0.00008103753,0.004338969,0.0009196603,0.002461136,0.01401422,0.01503775,0.004305431,0.0004305866,0.05743948],"study_design_scores_gemma":[0.0001049954,0.0003762077,0.9570858,0.00004290871,0.0004776231,0.0008794022,0.0003030849,0.03077478,0.001708824,0.007465066,0.0007207501,0.00006066028],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781829,0.0001401063,0.02035191,0.00008542144,0.00001490627,0.00003774461,0.0002698009,0.0000458514,0.0008712513],"genre_scores_gemma":[0.9970031,0.00005115835,0.002387732,0.00002712642,0.000006539574,0.00002052329,0.0003803624,0.00001726127,0.0001061912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01648274,"threshold_uncertainty_score":0.08717012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02103434921342973,"score_gpt":0.330789409689605,"score_spread":0.3097550604761753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}