{"id":"W4411429312","doi":"10.1016/j.ard.2025.05.283","title":"OP0273 CERTOLIZUMAB PEGOL TO PREVENT ADVERSE PREGNANCY OUTCOMES IN PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME AND LUPUS ANTICOAGULANT (IMPACT): RESULTS OF A PROSPECTIVE, SINGLE ARM, OPEN-LABEL, PHASE 2 TRIAL","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; CReATe Fertility Centre; Ottawa Fertility Centre; University of Toronto","funders":"","keywords":"Medicine; Certolizumab pegol; Antiphospholipid syndrome; Lupus anticoagulant; Open label; Adverse effect; Pregnancy; Internal medicine; Thrombosis; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003480165,0.001917154,0.002019543,0.0004390441,0.0003039742,0.001450155,0.0008416385,0.001812538,0.004365397],"category_scores_gemma":[0.00268831,0.000530279,0.001708393,0.0005152326,0.001111977,0.0010864,0.0003732282,0.002777031,0.000510609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008738281,"about_ca_system_score_gemma":0.001331923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007358063,"about_ca_topic_score_gemma":0.001327908,"domain_scores_codex":[0.9991432,0.0004137867,0.00005288685,0.0001308104,0.000106277,0.000153037],"domain_scores_gemma":[0.9986826,0.0004018318,0.0003279322,0.00008132373,0.00008203225,0.0004242322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9429798,0.01294739,0.003546114,0.0008341078,0.00172382,0.0001511711,0.0001005101,0.0006008405,0.002949677,0.0001627006,0.001120774,0.032883],"study_design_scores_gemma":[0.8938493,0.09986906,0.004152117,0.00004782978,0.0007924961,0.0000838123,0.00002283659,0.0002673408,0.0002617513,0.000102624,0.000536534,0.00001452204],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829914,0.008878482,0.0004771693,0.001189978,0.000282808,0.002622835,0.001290588,0.00008136594,0.00218537],"genre_scores_gemma":[0.9848025,0.005487273,0.001047274,0.001809779,0.0006442678,0.002535293,0.001787916,0.00001919362,0.001866479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004365397,"threshold_uncertainty_score":0.01840508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04706207607641542,"score_gpt":0.3750567869153794,"score_spread":0.327994710838964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}