{"id":"W4411429702","doi":"10.21203/rs.3.rs-6810020/v1","title":"Novel Antifungal Compound Z247611722 Exhibits Antifungal Activity by Inhibiting Serine Palmitoyltransferase","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Vlaamse regering; Canadian Institutes of Health Research; KU Leuven; Genome Canada; Fonds Wetenschappelijk Onderzoek; Canadian Institute for Advanced Research","keywords":"Sphingolipid; Serine; Biology; Antifungal drug; Antifungal; Computational biology; Fluconazole; Gene; Candida albicans; Pharmacology; Genetics; Biochemistry; Enzyme; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007015197,0.0005775515,0.0007077536,0.0002877415,0.0001537947,0.0003670368,0.0003596898,0.0003448982,0.003696946],"category_scores_gemma":[0.00007221473,0.0001149161,0.0003133296,0.0003747777,0.0001781648,0.0002164724,0.0002652695,0.0004873972,0.001238236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002059689,"about_ca_system_score_gemma":0.000334453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005871959,"about_ca_topic_score_gemma":0.0005458611,"domain_scores_codex":[0.9999449,0.000004738092,0.000004656953,0.00001242174,0.00001417155,0.00001911271],"domain_scores_gemma":[0.9999814,0.000001288856,0.000004023158,0.00000193888,0.000002981213,0.000008281818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001299187,0.0002151423,0.0004111585,0.0003104922,0.00005242066,0.0006597025,0.0000163105,0.0006661493,0.9604817,0.0004286362,0.001208557,0.03425042],"study_design_scores_gemma":[0.0005282226,0.001915057,0.002445073,0.00001516633,0.000105008,0.001053397,0.00002094754,0.001565627,0.9762173,0.0001803112,0.01592907,0.00002493482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702278,0.01180374,0.003904583,0.0004371705,0.0002265268,0.0001806725,0.002293012,0.0005391312,0.01038724],"genre_scores_gemma":[0.9818243,0.004872179,0.002542953,0.0001575133,0.00003899219,0.00006279691,0.003259957,0.000038595,0.007202743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003696946,"threshold_uncertainty_score":0.01236755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05914850874207607,"score_gpt":0.3723138530913392,"score_spread":0.3131653443492632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}