{"id":"W4411431252","doi":"10.1016/j.ard.2025.05.375","title":"OP0374 Clinical Meaningfulness of Pain Improvements and Time to Onset of Pain Relief of a Novel OA Therapy: Analyses from a Randomised Controlled Phase 2 Trial with LEVI-04, a Novel Neurotrophin-3 Inhibitor","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Pain relief; Pain therapy; Physical therapy; Clinical trial; Randomized controlled trial; Pain management; Anesthesia; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01224605,0.002328399,0.003586904,0.0007429067,0.0005580463,0.001510718,0.001447416,0.002197063,0.007809634],"category_scores_gemma":[0.007760023,0.0007177386,0.006767494,0.001020797,0.001711487,0.001675343,0.0008421643,0.003338874,0.0006961921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00172813,"about_ca_system_score_gemma":0.002452699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002130898,"about_ca_topic_score_gemma":0.004611084,"domain_scores_codex":[0.992997,0.004811363,0.0005055558,0.0004656142,0.0006342772,0.0005862655],"domain_scores_gemma":[0.9934646,0.00266448,0.001836001,0.0004828861,0.0004892014,0.001062668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9850868,0.00283604,0.001105684,0.0006008239,0.004065574,0.00003184646,0.00003768252,0.0002369988,0.001030921,0.00004393839,0.0004983828,0.004425304],"study_design_scores_gemma":[0.882466,0.1047143,0.007452232,0.00004610978,0.003777828,0.00003541556,0.00003832418,0.0003403629,0.0004307611,0.0001184961,0.0005432317,0.00003681044],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9645219,0.007534033,0.001824733,0.001255084,0.0006962746,0.01591108,0.005843644,0.0001261513,0.002287013],"genre_scores_gemma":[0.9742597,0.00252391,0.002490512,0.001649667,0.0007281758,0.01298214,0.003085538,0.00004091493,0.002239379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01224605,"threshold_uncertainty_score":0.06476402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07854496551538065,"score_gpt":0.3886925617745453,"score_spread":0.3101475962591646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}