{"id":"W4411431464","doi":"10.1016/j.ard.2025.05.101","title":"OP0079 Clinical, Cellular Kinetics, Pharmacodynamics and Biomarker Data Up to 12 Months After YTB323 (Rapcabtagene Autoleucel), a Rapidly Manufactured CD19 CAR-T Therapy, From an Open-Label, Phase 1/2 Study in Severe Refractory SLE","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Pharmacodynamics; Biomarker; Pharmacology; Pharmacokinetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001815049,0.000606939,0.001045338,0.0003311719,0.0002694614,0.0007916202,0.0004507081,0.0007572439,0.003216683],"category_scores_gemma":[0.001049503,0.0001810459,0.0007046984,0.0004262245,0.0006268854,0.0005720535,0.0003047216,0.001968928,0.0008198958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000458098,"about_ca_system_score_gemma":0.0005902751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002669847,"about_ca_topic_score_gemma":0.0005316419,"domain_scores_codex":[0.9993058,0.0002835656,0.00005263591,0.00009515936,0.0001626048,0.0001001471],"domain_scores_gemma":[0.9984818,0.000420743,0.0004569606,0.0001294381,0.000131632,0.0003794642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5261658,0.02969564,0.06896074,0.001650988,0.002066697,0.001509528,0.0004508733,0.003959014,0.1691335,0.0003029593,0.007598168,0.1885062],"study_design_scores_gemma":[0.05264875,0.6530587,0.2385613,0.0001130814,0.001382609,0.002774938,0.000178119,0.001742655,0.03557902,0.0003745295,0.01347509,0.0001112608],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904496,0.002963713,0.0006752401,0.000167633,0.00003274483,0.0004812164,0.003114775,0.0000597781,0.002055234],"genre_scores_gemma":[0.9876897,0.001028927,0.0006705936,0.0004141856,0.0000808679,0.0004372484,0.00774279,0.00003165346,0.001903979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003216683,"threshold_uncertainty_score":0.0107609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1711146996053166,"score_gpt":0.4758479427257691,"score_spread":0.3047332431204525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}