{"id":"W4411433001","doi":"10.1016/j.ard.2025.05.402","title":"POS0005 Inhaled Pirfenidone as an innovative therapeutic approach to treat autoimmune ILD and other forms of Progressive Pulmonary Fibrosis: Phase 2b Study Design","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Pirfenidone; Pulmonary fibrosis; Idiopathic pulmonary fibrosis; Fibrosis; Immunology; Intensive care medicine; Internal medicine; Lung","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003789542,0.002376948,0.002571129,0.0006272565,0.0005404552,0.001505416,0.001269129,0.002802479,0.01137844],"category_scores_gemma":[0.001602655,0.0008276334,0.00195685,0.0005570058,0.001321849,0.001365528,0.0005533899,0.004196232,0.00248257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008255619,"about_ca_system_score_gemma":0.002446672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004435344,"about_ca_topic_score_gemma":0.0009531843,"domain_scores_codex":[0.9989993,0.0004916458,0.00005565328,0.0001461468,0.0001244068,0.0001829035],"domain_scores_gemma":[0.9990792,0.0001421197,0.0001740073,0.0001083799,0.0001174806,0.0003788673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8637996,0.07826506,0.00165079,0.001728517,0.001438804,0.0001582301,0.00009795862,0.0008970344,0.01353432,0.0005767245,0.003689337,0.03416353],"study_design_scores_gemma":[0.7426175,0.2502117,0.001512389,0.00005797238,0.0003714801,0.00009059636,0.00002528499,0.0003870081,0.0009403011,0.0002982702,0.003468061,0.00001925093],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.8840212,0.008908926,0.005503935,0.00256849,0.001741466,0.0787198,0.008812089,0.0004129255,0.009311154],"genre_scores_gemma":[0.8300005,0.00778931,0.01443597,0.006591592,0.001849782,0.1145385,0.008710923,0.0001307326,0.01595266],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01137844,"threshold_uncertainty_score":0.03806466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04320937028852039,"score_gpt":0.3569841236719207,"score_spread":0.3137747533834003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}