{"id":"W4411434694","doi":"10.2196/68113","title":"Sustained Virological Response as a Surrogate Marker for Mortality, Decompensated Cirrhosis, or Hepatocellular Carcinoma in People With Chronic Hepatitis C Virus Infection Treated With Direct-Acting Antivirals: Protocol for a Bayesian and Causal Mediation Analysis","year":2025,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Hepatitis C virus research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Hepatocellular carcinoma; Medicine; Cirrhosis; Surrogate endpoint; Internal medicine; Protocol (science); Chronic hepatitis; Hepatitis B virus; Hepatitis C virus; Virology; Intensive care medicine; Virus; Oncology; Gastroenterology; Pathology; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08117507,0.004448065,0.007091085,0.003904043,0.0033895,0.003862351,0.00362878,0.008786992,0.06566303],"category_scores_gemma":[0.1010374,0.002449184,0.01572029,0.003794129,0.003284111,0.003258473,0.003641951,0.008481437,0.01325244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01034267,"about_ca_system_score_gemma":0.03390399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004309375,"about_ca_topic_score_gemma":0.006740797,"domain_scores_codex":[0.9585454,0.02527391,0.008423832,0.002633179,0.00308471,0.002038861],"domain_scores_gemma":[0.9524242,0.01879574,0.006597532,0.005391722,0.01466768,0.002123002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1539586,0.006029312,0.004566378,0.3475214,0.00972124,0.00193345,0.006348743,0.01612705,0.00603094,0.04675765,0.2076996,0.1933056],"study_design_scores_gemma":[0.2289744,0.01937072,0.01255962,0.1667253,0.01170933,0.0009202452,0.002261681,0.01211534,0.006647084,0.0520727,0.485462,0.001181529],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.0005296565,0.0002849888,0.002118806,0.0004370831,0.0002003472,0.9928964,0.002743662,0.00005943794,0.0007296438],"genre_scores_gemma":[0.0003759692,0.0001290925,0.002710644,0.00008995019,0.00001500068,0.9961985,0.0003032034,0.000003584342,0.0001740587],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.08117507,"threshold_uncertainty_score":0.4292999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1098603454715846,"score_gpt":0.4990478658071434,"score_spread":0.3891875203355588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}